| ファイル情報(添付) |
Sim3 Shares Some Common Roles With the Histone Chaperone Asf1 in Fission Yeast
9.63 MB
エンバーゴ :
2020-03-30
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| タイトル |
Sim3 Shares Some Common Roles With the Histone Chaperone Asf1 in Fission Yeast
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| 著者 |
Tanae Katsuhiro
Horiuchi Tomitaka
Yamakawa Takuya
Matsuo Yuzy
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| 収録物名 |
FEBS Letters
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| 巻 | 586 |
| 号 | 23 |
| 開始ページ | 4190 |
| 終了ページ | 4196 |
| 収録物識別子 |
EISSN 1873-3468
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| 内容記述 |
その他
An H3/H4 histone chaperone, Asf1, plays an essent ial role in maintaining genomic stabil i ty in many species, including f ission yeast . Here, we showed that overexpression of a CENP-A chaperone Sim3 suppres sed the temperature sensi t i ve phenotype of asf1-33 and asf1-30 mutants and the defect in chromat in st ructure, and prevented the accumulat ion of DNA damage in asf1-33 mutants at high temperatures. Fur thermore, asf1-33 and Δsim3 were synthet ic lethal . Consistent with this, shutdown of s im3 expression in asf1-33 Δsim3 double mutants that contained extragenic s im3 resul ted in growth retardat ion. In addi t ion, the Δs im3 mutant displayed sens i t ivi ty to thiabendazol and hydroxyurea, which suggests that Sim3 plays a general role in maintaining chromatin st ructur e . Our resul ts sugges t a possibil i ty that Sim3 funct ions as a histone chaperone.
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| 主題 | |
| 言語 |
英語
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| 資源タイプ | 学術雑誌論文 |
| 出版者 |
the Federation of European Biochemical Societies Edited by: Felix Wieland
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| 発行日 | 2012-11-30 |
| 出版タイプ | Accepted Manuscript（出版雑誌の一論文として受付されたもの。内容とレイアウトは出版社の投稿様式に沿ったもの） |
| アクセス権 | オープンアクセス |
| 関連情報 |
[DOI] 10.1016/j.febslet.2012.10.020
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| 備考 | This is the peer reviewed version of the following article: https://febs.onlinelibrary.wiley.com/doi/full/10.1016/j.febslet.2012.10.020, which has been published in final form at https://doi.org/10.1016/j.febslet.2012.10.020. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. |
