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language
eng
Attribute
Original article
Author
MIYAJI, Aoi
AKIHO, Mitsuki
MANAKO, Takuya
NAGANO, Satoru
Description
Qualitative changes in the extracellular matrix have been reported in thickened ligamentum flavum (LF) in lumbar spinal canal stenosis (LSCS); however, no detailed quantitative reports are available to date. Degenerated and undegenerated LF were collected from patients who underwent decompression surgery for LSCS and lumbar disc herniation, respectively. Three cylindrical samples of 2.5 mm diameter were cut from one LF specimen, completely solubilized, and quantified glycosaminoglycan (GAG), collagen (COL), and elastin. The amounts of GAG, COL, and elastin in the LSCS group were significantly higher than those in the control group. Although the GAG was originally present only in trace amounts, GAG proportion, standardized by dry weight, was the highest increase rate. Besides component analysis, histologic analysis showed intraligamentous chondrometaplasia in the caudal portion of the degenerated LF. Increased GAG in LF may be a new therapeutic target in LSCS.
Subject
lumbar spinal canal stenosis
ligamentum flavum
glycosaminoglycan
collagen, elastin
Journal Title
Shimane Journal of Medical Science
Volume
40
Issue
1-2
Start Page
1
End Page
8
ISSN
03865959
ISSN(Online)
24332410
Published Date
2023-06
NCID
AA00841586
DOI
Publisher
Faculty of Medicine, Shimane University
Publisher Aalternative
島根大学医学部
NII Type
Departmental Bulletin Paper
Format
PDF
Rights
Faculty of Medicine, Shimane University
rights(link)
Text Version
出版社版
OAI-PMH Set
Faculty of Medicine
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