Aerobic Oxidative C–H Azolation of Indoles and One-Pot Synthesis of Azolyl Thioindoles by Flavin–Iodine-Coupled Organocatalysis

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File	Aerobic Oxidative C–H Azolation of Indoles and One-Pot Synthesis of Azolyl Thioindoles by Flavin–Iodine-Coupled Organocatalysis 1.28 MB
language	eng
Author	Tanimoto, Kazumasa Department of Chemistry, Graduate School of Natural Science and Technology, Shimane University, 1060 Nishikawatsu, Matsue, 690-8504, Japan Okai, Hayaki Department of Chemistry, Graduate School of Natural Science and Technology, Shimane University, 1060 Nishikawatsu, Matsue, 690-8504, Japan Oka, Marina Department of Chemistry, Graduate School of Natural Science and Technology, Shimane University, 1060 Nishikawatsu, Matsue, 690-8504, Japan Ohkado, Ryoma Department of Chemistry, Graduate School of Natural Science and Technology, Shimane University, 1060 Nishikawatsu, Matsue, 690-8504, Japan Iida, Hiroki
Description	The aerobic oxidative cross-coupling of indoles with azoles driven by flavin-iodine-coupled organocatalysis has been developed for the green synthesis of 2-(azol-1-yl)indoles. The coupled organocatalytic system enabled the one-pot three-component synthesis of 2-azolyl-3-thioindoles from indoles, azoles, and thiols in an atom-economical manner by utilizing molecular oxygen as the only sacrificial reagent.
Subject	Oxidation reactions Flavins Chemical synthesis,Indoles Cross coupling reaction
Journal Title	Organic Letters
Volume	23
Issue	6
Start Page	2084
End Page	2088
ISSN	1523-7060
ISSN（Online）	1523-7052
Published Date	2021-03-19
DOI	10.1021/acs.orglett.1c00241
Publisher	American Chemical Society
NII Type	Journal Article
Format	PDF
Text Version	著者版
Gyoseki ID	38962
OAI-PMH Set	Faculty of Science and Engineering