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language
eng
Attribute
Review
Author
SANUKI, Tsuyoshi
OOUCHI, Sachiko
KAWASHIMA, Kosaku Department of Internal Medicine II, Shimane University Faculty of Medicine
ISHIHARA, Shunji Department of Internal Medicine II, Shimane University Faculty of Medicine
Description
Chronic diarrhea is a symptom frequently noted in patients with various diseases. In addition to organic conditions, such as inflammatory bowel and neoplastic diseases, functional diseases including irritable bowel syndrome are important etiological factors related to chronic diarrhea. According to recent reports, approximately one-third of cases with suspected irritable bowel syndrome are actually diagnosed as bile acid diarrhea, which is characterized by decreased absorption of bile acids from the terminal ileum as well as their hepatic overproduction. Clinical signs and symptoms of bile acid diarrhea do not differ from those of other diseases complicated with chronic diarrhea, and reliable laboratory tests for proper diagnosis are not available in Japan. On the other hand, effective treatment is possible with oral administration of bile acid sequestrants. Therefore, in cases of irritable bowel syndrome with diarrhea and functional diarrhea, the possibility of bile acid diarrhea should always be considered, with a treatment trial with bile acid sequestrants discussed herein as an option.
Subject
diarrhea
etiology
colestimide
bile acid
ileum
Journal Title
Shimane Journal of Medical Science
Volume
38
Issue
3
Start Page
89
End Page
97
ISSN
03865959
ISSN(Online)
24332410
Published Date
2021-09
NCID
AA00841586
Publisher
Faculty of Medicine, Shimane University
Publisher Aalternative
島根大学医学部
NII Type
Departmental Bulletin Paper
Format
PDF
Rights
Faculty of Medicine, Shimane University
Text Version
出版社版
OAI-PMH Set
Faculty of Medicine