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eng
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Description
Growth factors have recently gained clinical importance for wound management. Application of recombinant growth factors has been shown to mimic cell migration, proliferation, and differentiation in vivo, allowing for external modulation of the healing process. Perioperative drug delivery systems can enhance the biological activity of these growth factors, which have a very short in vivo half-life after topical administration. Although the basic mechanisms of these growth factors are well understood, most have yet to demonstrate a significant impact in animal studies or small-sized clinical trials. In this review, we emphasized currently approved growth factor therapies, including a sustained release system for growth factors, emerging therapies, and future research possibilities combined with surgical procedures. Approaches seeking to understand wound healing at a systemic level are currently ongoing. However, further research and consideration in surgery will be needed to provide definitive confirmation of the efficacy of growth factor therapies for intractable wounds.
Subject
Wound healing
Growth factor
Surgical application
Journal Title
Burns & Trauma
Volume
7
ISSN
2321-3876
Published Date
2019-04-05
DOI
Publisher
Oxford University Press
NII Type
Journal Article
Format
PDF
Text Version
出版社版
Gyoseki ID
e37105
OAI-PMH Set
Faculty of Medicine