number of downloads : ?
File
language
jpn
Title Transcription
アラドキン サン ホキュウ ノ アンゼンセイ ニ カンスル ケンキュウ アラドキン サン トウヨ ガ ノウ キノウ ニ オヨボス エイキョウ
Title Alternative (English)
Effects of chronic supplementation of arachidonic acid on the brain function in rodents
Author
Moriguchi, Toru School of Life and Environmental Science, Azabu University
Hashimoto, Michio
Description
Arachidonic acid (20:4n-6, ARA), which is one of the n-6 essential fatty acids, has been accumulated about 10% of the total fatty acids in a rodent brain. We investigated the effects in the brain function after chronic supplementation of ARA. The chronic supplementation of ARA increased motor activity, and reduced the total time which is the time until taking the diet, in the radial maze test as the spatial cognitive function test, although ARA did not indicate severe toxicity. A decrease in brain function was also observed in the rota-rod test as the motor coordination test. In the fatty acid composition of brain, we detected the increase of the total n-6 fatty acids and the decrease of DHA as the n-3 fatty acid in the ARA supplementation group, but there were no differences in saturated and monounsaturated fatty acids. This change of the n-3 Def group was more remarkable than that of the n-3 Adq group. Therefore, the chronic supplementation of ARA should be careful because there is a risk of deterioration of brain function based on the enhancement in n-3 fatty acids deficiency.
Subject
アラキドン酸
慢性投与
脳機能
げっ歯類
Arachidonic acid
Chronic supplementation
Brain function
Rodents
Journal Title
Journal of Lipid Nutrition
Volume
22
Issue
2
Start Page
165
End Page
172
ISSN
1883-2237
ISSN(Online)
1343-4594
Published Date
2013
DOI
Publisher
日本脂質栄養学会
Publisher Transcription
ニホン シシツ エイヨウ ガッカイ
NII Type
Journal Article
Format
PDF
Text Version
出版社版
Gyoseki ID
e21605
OAI-PMH Set
Faculty of Medicine