File
language
eng
Attribute
original article
Author
Tatano, Yutaka
Shimizu, Toshiaki
Tomioka, Haruaki
Description
Immunosuppressive macrophages (Mφs) generated in the spleen of Mycobacterium intracellulare (Min)-infected mice (Min-Mφs) exhibit suppressor activity against T cell mitogenesis in response to concanavalin A. Here, we attempted to fractionate the Min-Mφs population generated in Min-infected BALB/c mice at week 2 after infection. Min-Mφs were found to consist of two distinct subpopulations differing in their adhesiveness to plastic wells. The strongly adhesive Mφs population (SA-Mφs) exhibited marked suppressor activity. The weakly adhesive Mφ population (WA-Mφs) exhibited much less suppressor activity. Both SA-Mφs and WA-Mφs possessed a CDllb+F4/80+SR-AI+CDl4+ CD206+ phenotype characteristic of matured Mφs, generated reactive oxygen intermediates, and suppressed IL-2 receptor expression by concanavalin A-stimulated T cells. Moreover, their suppressor activities were dependent on prostaglandin. These findings indicate that Min infection in mice generates two types of immuosuppressive Mφs with different levels of suppressor activity.
Journal Title
Shimane journal of medical science
Volume
26
Start Page
1
End Page
7
ISSN
03865959
ISSN(Online)
24332410
Published Date
2009-12-01
NCID
AA00841586
Publisher Aalternative
Shimane University Faculty of Medicine
NII Type
Departmental Bulletin Paper
Format
PDF
Text Version
出版社版
OAI-PMH Set
Faculty of Medicine
Remark
http://ci.nii.ac.jp/vol_issue/nels/AA00841586_jp.html