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language
eng
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Original article
Author
JAYA, Muhammad Alim
HAYASHIDA, Maiko
TSUCHIE, Keiko
JERIN, Sultana Jannatul Ferdoush
MAMUNUR, Rahman
MIURA, Shoko
MIYAOKA, Tsuyoshi
TANRA, Andi Jayalangkara
HORIGUCHI, Jun
Description
Depression is one of the most common mental disorders. Glial cells have been reported to play a role in the pathogenesis of depression. Meanwhile, Ninjin’yoeito (NYT), a Kampo medicine, is a multi-component drug that was reported to improve depressive symptoms in patient and animal models. In addition, some of its components have an effect on glial cells. However, the mechanism remains unclear. The study’s aim was to investigate the effect of NYT in recovering depressive-like behavior and glial pathological changes in the hippocampus induced by lipopolysaccharide. Here, we showed that NYT improved the forced swim test performances of the rat. Furthermore, NYT also inhibited microglial activation in the hippocampus, but the results were different in astrocytes. These results suggest that NYT alleviates depressive-like behavior, and the effect may be associated with the attenuation of glial cell activation.
Subject
ninjin’yoeito
kampo medicine
depressive behavior
glial cells
lipopolysaccharide
forced swim tests
Journal Title
Shimane Journal of Medical Science
Volume
39
Issue
1
Start Page
1
End Page
13
ISSN
03865959
ISSN(Online)
24332410
Published Date
2022-03
NCID
AA00841586
DOI
Publisher
Faculty of Medicine, Shimane University
Publisher Aalternative
島根大学医学部
NII Type
Departmental Bulletin Paper
Format
PDF
Rights
Faculty of Medicine, Shimane University
rights(link)
Text Version
出版社版
OAI-PMH Set
Faculty of Medicine
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