File
language
eng
Attribute
case report
Author
Kataoka, Shingo
Kato, Taiji
Sano, Keisuke
Ogasawara, Keiko
Ohga, Hisashi
Description
We reported a rare case of malignant parotid tumor with a severe granulocytosis, which was induced by granulocyte colony stimulating factor (GCSF) produced from tumor cells. A 59-year-old male patient had shown a marked leukocytosis with up to 27,100/mm3 and a larger number of mature granulocytes in peripheral blood leukocytes. The level of G-CSF in serum was obviously high (263.0 pg/ml). We undertook a total parotidectomy and left radical neck dissection, but the tumor resection was not completely performed because of an extensive invasion to the left carotid artery and parapharyngeal space as well. The pathological diagnosis was poorly-differentiated adenocarcinoma. The patient died about 4 months after being admitted to our hospital, even though a systemic chemotherapy was followed after the surgical treatment. We diagnosed this case as a G-CSF producing malignant parotid tumor, because high G-CSF activity was detected in the tumor secretion, cancerous pleural effusion and culture supernatant of tumor cells, respectively. This diagnosis was further confirmed by the finding that GCSF gene transcripts were detected in tumor cells of this patient.
Journal Title
Shimane journal of medical science
Volume
21
Issue
1
Start Page
7
End Page
12
ISSN
03865959
ISSN(Online)
24332410
Published Date
2003-06-01
NCID
AA00841586
Publisher Aalternative
Shimane Medical University
NII Type
Departmental Bulletin Paper
Format
PDF
Text Version
出版社版
OAI-PMH Set
Faculty of Medicine
Remark
http://ci.nii.ac.jp/vol_issue/nels/AA00841586_jp.html