File
language
eng
Author
Zhang, Hao
Ma, Lang
Hatta, Toshihisa
Description
The temporal profile of fetal-maternal adrenocortical activities, including blood corticosterone concentration and adrenal expression of cytochrome P45011ß, approaching parturition was investigated in mice. The fetal serum corticosterone concentration reached a peak on gestational day (G) 17 and maternal serum corticosterone reached a highest value on G15 and then subsequently decreased. Fetal and maternal adrenal expression of cytochrome P45011ß increased with advancing pregnancy before the blood corticosterone concentrations reached each peak but then did not change substantially until the term. The results suggest that the increases of blood fetalmaternal corticosterone concentrations before peak are contributed by the increased adrenocortical activities, whereas the subsequent drops after peaks are not adrenocortical dependent. Other possible factors responsible for the drop such as placental catabolism, tissue utilization and liver metabolism are discussed.
Journal Title
Shimane journal of medical science
Volume
18
Issue
1
Start Page
5
End Page
9
ISSN
03865959
ISSN(Online)
24332410
Published Date
2000-06-01
NCID
AA00841586
Publisher Aalternative
Shimane Medical University
NII Type
Departmental Bulletin Paper
Format
PDF
Text Version
出版社版
OAI-PMH Set
Faculty of Medicine
Remark
http://ci.nii.ac.jp/vol_issue/nels/AA00841586_jp.html