File
language
eng
Attribute
original article
Author
Takatsuka, Hisakazu
Fujii, Yoshimi
Hsiao-Chi, Chung
Muro, Tomonori
Kataoka, Kaori
Description
Deoxyribonuclease I (DNase I) polymorphism n exon 8 (A2317G) designated as DNASEI is considered to be one of the susceptibility genes for gastric and colorectal carcinoma, and myocardial infarction. Moreover, the presence of a variable number of tandem repeat (VNTR) polymorphism, designated as HumDN1, in intron 4. was found. In this study, the simultaneous genotyping of DNASEI and HumDN1 polymorphisms within the DNase I gene was performed in Ovambo, Turk, Mongolian, Korean and Japanese populations. Genotype distributions of DNASEI and HumDNI Ioci differed among these populations. While there was a general uniformity for the two polymorphisms in the three Asian populatlons, a significant difference in genotype distribution were found between the Ovambo and Turk populations. The DNASE1*1 and HumDN1*3 alleles were found to be the most predominant in the Ovambos, with the Turks showing the highest allele frequency for DNASE1*2, HumDN1*4 and HumDN1*5. From this study, there was the existence of a certain genetic heterogeneity in the distribution of these two DNase l polymorphisms. Furthermore, linkage disequilibrium between these two polymorphisms was revealed in all of the populations except the Ovambos. The combination of the two polymorphisms within a DNase I gene may be potentially useful for clinical purposes and in population genetic studies.
Journal Title
Shimane journal of medical science
Volume
24
Start Page
15
End Page
20
ISSN
03865959
ISSN(Online)
24332410
Published Date
2007-12-01
NCID
AA00841586
Publisher Aalternative
Shimane University Faculty of Medicine
NII Type
Departmental Bulletin Paper
Format
PDF
Text Version
出版社版
OAI-PMH Set
Faculty of Medicine
Remark
http://ci.nii.ac.jp/vol_issue/nels/AA00841586_jp.html