File
language
eng
Author
Shimoura, Keiko
Kakizoe, Eiichi
Yokoyama, Satoshi
Wang, Dan-Qiao
Okunishi, Hideki
Description
Previous studies in rats demonstrated that the inhibition of vascular tissue angiotensin-converting enzyme (ACE) was the determinant of antihypertensive action
of an ACE inhibitor, whereas plasma ACE inhibition was not. In patients, however, it is not practical to perform vascular tissue-biopsy merely to estimate drug effects. Therefore, the present study examined in rats practical to perform vascular tissue-biopsy merely to estimate drug effects. Therefore, the present study examined in rats whether or not peripheral blood lymphocytes (PBL) could be used as a surrogate marker for aortic tissue in respect of tissue ACE inhibition. Rats were treated daily for 6 days with one of the three ACE inhibitors (captopril, enalapril, and trandolapril) bearing different pharmacokinetic properties from each other. At a certain time after the final dosing, PBL and various tissues were harvested to measure ACE activity ex vivo. The present results confirmed the previous data for ACE inhibition in aorta and other tissues. Unexpectedly, however, ACE activity ex vivo of PBL was not reduced at all by any of the drug treatments, suggesting some drug-efflux mechanisms involved. In conclusion, PBL could not be used as the surrogate marker to estimate the vascular tissue ACE inhibition.
Journal Title
Shimane journal of medical science
Volume
18
Issue
2
Start Page
43
End Page
52
ISSN
03865959
ISSN(Online)
24332410
Published Date
2000-12-01
NCID
AA00841586
Publisher Aalternative
Shimane Medical University
NII Type
Departmental Bulletin Paper
Format
PDF
Text Version
出版社版
OAI-PMH Set
Faculty of Medicine
Remark
http://ci.nii.ac.jp/vol_issue/nels/AA00841586_jp.html