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language
eng
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Review
Author
Description
The genome is carried by the complete linear sequence of DNA nucleotides packaged into all the chromosomes. During interphase, the chromosomes are extended and much of their chromatin exist as long threads while also maintaining specific three-dimensional architectures in the nuclear space. These interphase chromosomes are organized into multiscale three-dimensional structures, including chromosome territories, A/B compartments, topologically associating domains, and chromatin loops, that extend over a wide range of genomic distances, providing connections, for instance, between enhancers and promoters. This hierarchically organized genomic architecture is crucial for the regulation of gene transcription, which in turn is essential for the development and maintenance of various biological processes. This article reviews various aspects of spatial genome organization and their functions in gene expression and neural development. Furthermore, dysregulation of spatial genome organization in disease states, and the growing interest in new technologies to manipulate chromatin architecture are also discussed.
Subject
central nervous system
development
disease
3D genome
chromatin
Journal Title
Shimane Journal of Medical Science
Volume
39
Issue
3
Start Page
77
End Page
93
ISSN
03865959
ISSN(Online)
24332410
Published Date
2022-09
NCID
AA00841586
DOI
Publisher
Faculty of Medicine, Shimane University
Publisher Aalternative
島根大学医学部
NII Type
Departmental Bulletin Paper
Format
PDF
Rights
Faculty of Medicine, Shimane University
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出版社版
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Faculty of Medicine
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