Palmitate-induced lipotoxicity is crucial for the pathogenesis of nonalcoholic fatty liver disease in cooperation with gut-derived endotoxin

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language	eng
Author	Ogawa Yuji Department of Gastroenterology and Hepatology, Yokohama City University Graduate School of Medicine, Yokohama, 236-0004, Japan Imajo Kento Department of Gastroenterology and Hepatology, Yokohama City University Graduate School of Medicine, Yokohama, 236-0004, Japan Honda Yasushi Department of Gastroenterology and Hepatology, Yokohama City University Graduate School of Medicine, Yokohama, 236-0004, Japan Kessoku Takaomi Department of Gastroenterology and Hepatology, Yokohama City University Graduate School of Medicine, Yokohama, 236-0004, Japan Tomeno Wataru Department of Gastroenterology and Hepatology, Yokohama City University Graduate School of Medicine, Yokohama, 236-0004, Japan Kato Shingo Department of Gastroenterology and Hepatology, Yokohama City University Graduate School of Medicine, Yokohama, 236-0004, Japan Fujita Koji Department of Gastroenterology and Hepatology, Yokohama City University Graduate School of Medicine, Yokohama, 236-0004, Japan Yoneda Masato Department of Gastroenterology and Hepatology, Yokohama City University Graduate School of Medicine, Yokohama, 236-0004, Japan Saito Satoru Department of Gastroenterology and Hepatology, Yokohama City University Graduate School of Medicine, Yokohama, 236-0004, Japan Saigusa Yusuke Department of Biostatistics, Yokohama City University School of Medicine, Yokohama, 236-0004, Japan Hyogo Hideyuki Department of Gastroenterology and Hepatology, JA Hiroshima General Hospital, Hiroshima, 738-8503, Japan Sumida Yoshio Division of Hepatology and Pancreatology, Department of Internal Medicine, Aichi Medical University, Aichi, 480-1195, Japan Itoh Yoshito Department of Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Kyoto, 602-8566, Japan Eguchi Kosei Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo, Bunkyo, 113-8655, Japan Yamanaka Takeharu Department of Biostatistics, Yokohama City University School of Medicine, Yokohama, 236-0004, Japan Wada, Koichiro Nakajima Atsushi Department of Gastroenterology and Hepatology, Yokohama City University Graduate School of Medicine, Yokohama, 236-0004, Japan
Journal Title	SCIENTIFIC REPORTS
Volume	8
ISSN	2045-2322
Published Date	2018-07-27
DOI	10.1038/s41598-018-29735-6
PubMed ID	30054551
Publisher	NATURE PUBLISHING GROUP
NII Type	Journal Article
OAI-PMH Set	Faculty of Medicine
Remark	The skillful technical assistance of Machiko Hiraga and Ayaka Miura is gratefully acknowledged. This study was supported by the Japan Society for the Promotion of Science KAKENHI grant numbers 25860551 and 15K19340, and research grants from the Liver Forum in Kyoto. We thank Lynley Pound, Ph.D., from Edanz Group (www.edanzediting.com/ac) for editing a draft of this manuscript.