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PREGNANCY AND THYROID DISEASE
Author
Description
Background
The epidemiology and natural history of autonomously functioning thyroid nodules (AFTNs) have not been elucidated. Here we report the pregnant Japanese woman with an AFTN.

Case presentation
The patient was a 31-year-old woman who was hospitalized due to the placenta previa associated with threatened abortion at the 16 weeks of her third pregnancy. At her second pregnancy, she was euthyroid but had a single, 2.3 cm nodule on her right thyroid lobe. Her thyroid hormone level was trended increased with her pregnancy progression, and the thyrotoxic state was remained after delivery. Before her third pregnancy, her hyper-vascular nodule enlarged to 3.4 cm at regular monitoring. When she visited our hospital, she was at 16 weeks of pregnancy and had thyrotoxicosis with negative TSH-receptor antibody. She delivered a baby weighing 2615 g without hypothyroidism at 39 weeks of pregnancy by natural delivery. After delivery, a 99mTc scintigram showed a hot spot in her right thyroid lobe. She was diagnosed with AFTN and treated with methimazole while nursing.

Conclusions
This case showed that hCG stimulation during pregnancy caused thyroid nodule enlargement and enhanced thyroid hormone production. The pregnancy could be the pathological stimulus and provides chance to diagnosis for AFTNs.
Subject
Autonomously functioning
thyroid
nodule
epidemiology
pregnancy
hyperthyroidism
Journal Title
Gynecological Endocrinology
Volume
36
Issue
12
Start Page
1140
End Page
1143
ISSN
0951-3590
ISSN(Online)
1473-0766
Published Date
2020-09-21
DOI
Publisher
Informa Healthcare
NII Type
Journal Article
Format
PDF
Text Version
著者版
Gyoseki ID
39769
OAI-PMH Set
Faculty of Medicine
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