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File
language
eng
Attribute
Original article
Author
Mataga, Kentaro
Aoki, Akihiko
Himeno, Yasutoshi
Shigeno, Kazushi
Suzuki, Keiko
Description
Protein energy wasting, malnutrition-inflammation complex syndrome, and frailty are thought to affect mortality in chronic dialysis patients. We performed a historical cohort study to investigate effects of the nutritional status on cardiovascular (CV) and non-CV mortalities as well as CV events using Geriatric Nutritional Risk Index (GNRI). We registered patients undergoing maintenance hemodialysis (HD)therapy from January to March in 2006 to analyze mortality and causes of death in 7-years observation. A Kaplan-Meyer curve showed that the survival rate tends to be lower in 102 patients with GNRI<92, compared to 171 patients with GNRI ≧92. In a multivariate Cox proportional hazard analysis, the GNRI was an independent predictor for all-cause mortality with hazard ratio of 0.960 (95% confident interval: 0.928-0.993) after adjustment with age, gender, dialysis duration, blood access, the presence of diabetes mellitus, serum levels of calcium, phosphate, alkaline phosphatase, parathyroid hormone and C-reactive protein, and drug use of active vitamin D analog and non-calcium containing phosphate binders. The GNRI was not associated with CV death but with non-CV death after adjustment with the covariates. In parallel with these findings, there was no significant association between the GNRI and CV events. Nutritional status was significantly associated with non-CV death but not with CV death and CV events at least in our maintenance hemodialysis patients.
Subject
nutrition
hemodialysis
mortality
cardiovascular event
Journal Title
Shimane journal of medical science
Volume
33
Issue
2
Start Page
61
End Page
70
sort
2
ISSN
03865959
ISSN(Online)
24332410
Published Date
2017-03-01
NCID
AA00841586
SID
9189
Publisher
Shimane University Faculty of Medicine
DCMI
text
NII Type
Departmental Bulletin Paper
Format
PDF
Text Version
出版社版
OAI-PMH Set
Faculty of Medicine
Journal Code
Shimane Journal of Medical Science
Diploma Number
甲第649号
Granted Date
2019-3-22
Degree Name
博士(医学)
Grantor
島根大学
Graduate Course
Graduate School of Medical Research
Granted Year
2018
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