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language
eng
Author
Tahara, Nao Department of Neurology, Shimane University, Faculty of Medicine
Matsuda, Hanako Department of Neurology, Shimane University, Faculty of Medicine
Takayoshi, Hiroyuki Department of Neurology, Shimane University, Faculty of Medicine
Yamaguchi, Shuhei Department of Neurology, Shimane University, Faculty of Medicine
Description
Objective. We investigated recurrent stroke volume with nonvalvular atrial fibrillation (NVAF) patients treated with non-vitamin K antagonist oral anticoagulants (NOACs) about clinical backgrounds and number of recurrent stroke.
Methods. We administered four NOACs, dabigatran, rivaroxaban, apixaban and edoxaban in 101 post cardioembolic stroke with NVAF. In retrospective study, we measured recurrent stroke volume with MRI volumetric soft and compared them between 10 vitamin K anticoagulant (VKA: warfarin) cases and 13 NOACs cases under anticoagulant therapy.
Results. Of 101 cases, 31 cases were started with VKA and switched to NOACs after 10 recurrent strokes. Other 70 cases were directly started with NOACs and 13 cases with NOACs as first anticoagulants had recurrent stroke. The frequency of recurrent stroke during anticoagulant therapy are not different among VKA group and three NOACs group. Recurrent stroke volume is significantly larger in VKA group (26.4 cm3) than in NOACs group (3.8cm3).
Conclusions. Secondary prevention with NOACs after stroke might be more beneficial by reducing recurrent infarct volume than VKA.
Journal Title
Journal of Stroke and Cerebrovascular Diseases
Volume
27
Issue
2
Start Page
338
End Page
345
ISSN
1052-3057
Published Date
2018-02
DOI
PubMed ID
Publisher
New York, NY : Demos Publications, [1991-]
NII Type
Journal Article
Format
PDF
Text Version
著者版
OAI-PMH Set
Faculty of Medicine
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