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language
eng
Author
Miyake, Hitomi Department of Internal Medicine 1, Shimane University Faculty of Medicine
Kanazawa, Ippei Department of Internal Medicine 1, Shimane University Faculty of Medicine
Sugimoto, Toshitsugu Department of Internal Medicine 1, Shimane University Faculty of Medicine
Description
Objective: Previous studies have shown that serum insulin-like growth factor-I (IGF-I) is involved in diabetes-related bone fragility. Although lower serum levels of IGF-I are reported to be associated with a higher risk of vertebral fractures in patients with type 2 diabetes, it is unknown whether or not the serum level of IGF-I is associated with the incidence of non-vertebral fractures.
Methods: We investigated the relationships between the serum levels of IGF-I and the incidence of non-vertebral osteoporotic fractures in 188 men and 168 postmenopausal women with type 2 diabetes.
Results: A multiple logistic regression analysis adjusted for age, duration of diabetes, observation period, body mass index, HbA1c, serum creatinine, and the bone mineral density at the lumbar spine showed that the serum IGF-I level was significantly and inversely associated with the incidence of non-vertebral osteoporotic fractures in postmenopausal women (odds ratio =0.48, 95% confidential interval [CI] 0.23-0.99 per SD increase; p=0.047), but not in men. Moreover, the inverse association between the serum IGF-I level and the incidence of non-vertebral fractures remained significant after additional adjustment for insulin use, and the serum calcium and phosphate levels (odds ratio =0.48, 95% CI 0.23-0.99 per SD increase; p=0.046).
Conclusion: This is the first study to show that decreased serum IGF-I levels are associated with a higher risk of non-vertebral osteoporotic fractures in postmenopausal women with type 2 diabetes. Serum IGF-I could be a useful marker for assessing the incidence of osteoporotic fractures.
Subject
insulin-like growth factor-I
type 2 diabetes mellitus
fracture
non-vertebral fractures
Journal Title
Internal medicine
Volume
56
Issue
3
Start Page
269
End Page
273
ISSN
13497235
Published Date
2017-02-01
DOI
PubMed ID
NCID
AA12022491
Publisher
Japanese Society of Internal Medicine
Publisher Aalternative
日本内科学会
NII Type
Journal Article
Format
PDF
Rights
Copyright © 2017 by The Japanese Society of Internal Medicine
OAI-PMH Set
Faculty of Medicine
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