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language
eng
Attribute
Original article
Author
GONG , AO
HASEGAWA, Masahiro
HATTORI, Tetsuya
SUDO, Akihiro
Description
Osteoarthritis (OA) is a degenerative disorder that is characterized by articular cartilage destruction. The level of tenascin-C (TNC), an extracellular matrix protein, is increased in synovial fluid (SF) from OA patients, and TNC concentration in SF correlates with the severity of OA in the knee. Tenascin-X (TNX), another member of the tenascin family, has been identified as a causative protein of classical-like Ehlers-Danlos syndrome (clEDS). In this study, we investigated the correlation between TNX concentration and the degree of cartilage denaturation in OA patients. TNX concentrations in SF from patients with meniscus tears and from OA patients were lower than those of control sera. However, significant difference in TNX concentration in SF was not observed between patients with meniscus tears and OA patients. Furthermore, a significant correlation was not found between TNX concentration in SF and severity of OA in the knees of patients. These results suggest that TNX might not be as useful as TNC as a biomarker.
Subject
osteoarthritis
tenascin-X
synovial fluid
Journal Title
Shimane Journal of Medical Science
Volume
37
Issue
4
Start Page
117
End Page
121
ISSN
03865959
ISSN(Online)
24332410
Published Date
2020-12
NCID
AA00841586
Publisher
Faculty of Medicine, Shimane University
Publisher Aalternative
島根大学医学部
NII Type
Departmental Bulletin Paper
Format
PDF
Rights
Faculty of Medicine, Shimane University
Text Version
出版社版
OAI-PMH Set
Faculty of Medicine
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