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language
eng
Attribute
original article
Author
Shimizu, Kanako
Tamura, Yukie
Sano, Keisuke
Kimura, Mitsuhiro
Murata, Akemichi
Description
We conducted a well-controlled observational study attempting to examine whether decreased cognitive functions caused by Japanese cedar pollinosis could be improved by oral administration of fexofenadine hydrochloride particularly in school-age patients. Cognitive functions were evaluated before and after the treatment by employing Trail Making tests (TMT). Participating patients answered a questionnaire about treatment effects and their satisfaction with fexofenadine hydrochloride. A total of 54 patients aged 7 to 16 were enrolled in this study. A significant improvement was observed with two kinds of TMT (P<0.0001 for both). The overall ratio of positive answers to the question of overall satisfaction with the drug, concentration in the classroom, symptoms, inconvenience in daily life, and night-time sleep were 88.5%, 71.1%, 88.7%, 60.0%, and 65.3%, respectively. These results taken together suggest that treatment with fexofenadine hydrochloride actually restores nasal symptom-derived decreases in cognitive functions, with no impairment of cognitive functions by the central nervous system (CNS) depressant actions.
Subject
pollinosis
antihistamines
school-age
CNS depression
cognitive function
observational study
Journal Title
Shimane journal of medical science
Volume
29
Issue
2
Start Page
79
End Page
86
ISSN
03865959
ISSN(Online)
24332410
Published Date
2013-02-01
NCID
AA00841586
Publisher
Shimane University Faculty of Medicine
NII Type
Departmental Bulletin Paper
Format
PDF
Text Version
出版社版
Gyoseki ID
e22158
e22160
e22167
e22168
e22159
OAI-PMH Set
Faculty of Medicine
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