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language
eng
Author
Okada, Kazunori
Kobayashi, Shotai
Kono, Naoto
Yamagata, Shingo
Yamaguchi, Shuhei
Description
We present a patient with nonketotic hyperosmolar coma who exhibited extra-pontine myelinolysis as demonstrated by the findings including magnetic resonance imaging (MRI). The lesions appeared as widespread symmetrical hyperintensities that involved the subcortical white matter of the frontal, temporal, and parietal lobes. Thinning of the cerebral cortices was observed. The center of the pons was only slightly affected. The patient ultimately died of pneumonia. The abrupt changes in serum sodium concentration and/or osmolarity, induced not only by treatment of hyponatremia, but by alteration to the hypernatremic state, may have contributed to the development of pontine and extra-pontine myelinolysis. To our knowledge, this is the first case in which the MRI results corresponded to previously reported autopsy findings of extra-pontine form by Okeda et al. in pontine and extra-pontine myelinolysis.
Subject
Hyperglycemia
Hypernatremia
Central pontine myelinolysis
Journal Title
Shimane journal of medical science
Volume
15
Start Page
1
End Page
3
ISSN
03865959
ISSN(Online)
24332410
Published Date
1997-09-01
NCID
AA00841586
Publisher Aalternative
Shimane Medical University
NII Type
Departmental Bulletin Paper
Format
PDF
Text Version
出版社版
OAI-PMH Set
Faculty of Medicine
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