number of downloads : ?
File
language
eng
Author
Ishikura, Hiroto
Tsumura, Hiroto
Nakashima, Akemi
Munemasa, Shoso
Sato, Yukie
Kobayashi, Shotai
Description
To study the stability of lineage commitment of acute promyelocytic leukemia (APL) cells, we treated freshly isolated leukemic cells from the patients with APL with various differentiation-inducers. APL cells showed granulocytic differentiation when treated with all-trans retinoic acid as previously reported. We showed here that freshly isolated APL cells could be also induced to differentiation to monocytic/macrophagic lineage with inducers such as 1,25 dihydroxyvitamin D3,12-O-tetradecanoylphorbol-13-acetate or tumor necrosis factor-α. These results suggest that APL cells have the capacity to differentiate toward not only granulocytic lineage but also monocytic/macrophagic macrophagic lineage. It is not clear that these results indicate the lineage promiscuity of normal promyelocytes or lineage infidelity of APL cells. However, these data provide an important clinical implication, because a possible therapeutic efficacy of using differentiation-inducing agents toward monocytic/macrophagic lineage in the remission induction therapy for the patient with APL or salvage therapy for the resistant APL cases to all-trans retinoic acid therapy is suggested.
Subject
acute promyelocytic leukemia
differentiation lnduction
Journal Title
Shimane journal of medical science
Volume
16
Issue
2
Start Page
37
End Page
39
ISSN
03865959
ISSN(Online)
24332410
Published Date
1998-12-01
NCID
AA00841586
Publisher Aalternative
Shimane Medical University
NII Type
Departmental Bulletin Paper
Format
PDF
Text Version
出版社版
OAI-PMH Set
Faculty of Medicine
このエントリーをはてなブックマークに追加