| File | |
| language |
eng
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| Author |
Demizu, Ryuta
Department of Chemistry, Graduate School of Natural Science and Technology, Shimane University, 1060 Nishikawatsu,Matsue 690-8504, Japan
Ohkado, Ryoma
Department of Chemistry, Graduate School of Natural Science and Technology, Shimane University, 1060 Nishikawatsu,Matsue 690-8504, Japan
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| Description | A green, aerobic sulfenylation of imidazo[ 1,2-a]pyridines was performed using thiols, a flavinand- iodine dual catalytic system, and environmentally benign molecular oxygen as the only sacrificial reagent. The dual metal-free catalysts smoothly promote a unique stepwise tandem process, beginning with the aerobic oxidation of a thiol to afford a disulfide that is utilized in the oxidative sulfenylation of the imidazo[1,2-a]pyridine. This process has afforded diverse 3-sulfenylimidazo[1,2-a]pyridines of biological interest, and is environmentally friendly as benign H2O is the only by-product.
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| Subject | Disulfides
Reagents
Flavins
Thiols
Catalysts
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| Journal Title |
The Journal of Organic Chemistry
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| Volume | 83
|
| Issue | 19
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| Start Page | 12291
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| End Page | 12296
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| ISSN | 0022-3263
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| ISSN（Online） | 1520-6904
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| Published Date | 2018-10-1
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| DOI | |
| Publisher | American Chemical Society
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| NII Type |
Journal Article
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| Format |
PDF
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| Rights | https://s100.copyright.com/AppDispatchServlet?startPage=12291&pageCount=6©right=American+Chemical+Society&author=Hiroki+Iida%2C+Ryuta+Demizu%2C+Ryoma+Ohkado&orderBeanReset=true&imprint=American+Chemical+Society&volumeNum=83&issueNum=19&contentID=acs.joc.8b01878&title=Tandem+Flavin-Iodine-Catalyzed+Aerobic+Oxidative+Sulfenylation+of+Imidazo%5B1%2C2-a%5DPyridines+with+Thiols&numPages=6&pa=&issn=0022-3263&publisherName=acs&publication=joceah&rpt=n&endPage=12296&publicationDate=October+2018
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| Text Version |
著者版
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| Gyoseki ID | e34995
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| OAI-PMH Set |
Faculty of Science and Engineering
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| Remark | J. Org. Chem. 2018, 83, 19, 12291-12296
|
