Prediction of tissue-of-origin of early stage cancers using serum miRNomes

Juntaro Matsuzaki 1 2, Ken Kato 3, Kenta Oono 4, Naoto Tsuchiya 5, Kazuki Sudo 6, Akihiko Shimomura 6, Kenji Tamura 6, Sho Shiino 7, Takayuki Kinoshita 8, Hiroyuki Daiko 9, Takeyuki Wada 10, Hitoshi Katai 10, Hiroki Ochiai 11, Yukihide Kanemitsu 11, Hiroyuki Takamaru 12, Seiichiro Abe 12, Yutaka Saito 12, Narikazu Boku 3, Shunsuke Kondo 13, Hideki Ueno 13, Takuji Okusaka 13, Kazuaki Shimada 14, Yuichiro Ohe 15, Keisuke Asakura 16, Yukihiro Yoshida 16, Shun-Ichi Watanabe 16, Naofumi Asano 17, Akira Kawai 17, Makoto Ohno 18, Yoshitaka Narita 18, Mitsuya Ishikawa 19, Tomoyasu Kato 19, Hiroyuki Fujimoto 20, Shumpei Niida 21, Hiromi Sakamoto 22, Satoko Takizawa 1 23, Takuya Akiba 4, Daisuke Okanohara 4, Kouya Shiraishi 24, Takashi Kohno 24, Fumitaka Takeshita 25, Hitoshi Nakagama 26, Nobuyuki Ota 27, Takahiro Ochiya 1 28; Project Team for Development and Diagnostic Technology for Detection of miRNA in Body Fluids 1Division of Molecular and Cellular Medicine, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan. 2Division of Pharmacotherapeutics, Keio University Faculty of Pharmacy, Minato-ku, Tokyo, Japan. 3Department of Head and Neck, Esophageal Medical Oncology and Department of Gastrointestinal Medical Oncology, National Cancer Center Hospital, Chuo-ku, Tokyo, Japan. 4Preferred Networks, Inc, Chiyoda-ku, Tokyo, Japan. 5Laboratory of Molecular Carcinogenesis, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan. 6Department of Breast and Medical Oncology, National Cancer Center Hospital, Chuo-ku, Tokyo, Japan. 7Department of Breast Surgery, National Cancer Center Hospital, Chuo-ku, Tokyo, Japan. 8Department of Breast Surgery, National Hospital Organization Tokyo Medical Center, Meguro-ku, Tokyo, Japan. 9Department of Esophageal Surgery, National Cancer Center Hospital, Chuo-ku, Tokyo, Japan. 10Department of Gastric Surgery, National Cancer Center Hospital, Chuo-ku, Tokyo, Japan. 11Department of Colorectal Surgery, National Cancer Center Hospital, Chuo-ku, Tokyo, Japan. 12Endoscopy Division, National Cancer Center Hospital, Chuo-ku, Tokyo, Japan. 13Department of Hepatobiliary and Pancreatic Oncology, National Cancer Center Hospital, Chuo-ku, Tokyo, Japan. 14Department of Hepatobiliary and Pancreatic Surgery, National Cancer Center Hospital, Chuo-ku, Tokyo, Japan. 15Department of Thoracic Oncology, National Cancer Center Hospital, Chuo-ku, Tokyo, Japan. 16Department of Thoracic Surgery, National Cancer Center Hospital, Chuo-ku, Tokyo, Japan. 17Department of Musculoskeletal Oncology, National Cancer Center Hospital, Chuo-ku, Tokyo, Japan. 18Department of Neurosurgery and Neuro-Oncology, National Cancer Center Hospital, Chuo-ku, Tokyo, Japan. 19Department of Gynecology, National Cancer Center Hospital, Chuo-ku, Tokyo, Japan. 20Department of Urology, National Cancer Center Hospital, Chuo-ku, Tokyo, Japan. 21Research Institute, National Center for Geriatrics and Gerontology, Obu, Aichi, Japan. 22Department of Biobank and Tissue Resources, Fundamental Innovative Oncology Core, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan. 23Toray Industries, Inc, Kamakura, Kanagawa, Japan. 24Division of Genome Biology, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan. 25Department of Translational Oncology, Fundamental Innovative Oncology Core, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan. 26National Cancer Center, Chuo-ku, Tokyo, Japan. 27Preferred Medicine, Inc, Burlingame, CA, USA. 28Department of Molecular and Cellular Medicine, Tokyo Medical University, Shinjuku-ku, Tokyo, Japan.

Tamura, Kenji