A prospective multicenter study on genome wide associations to ranibizumab treatment outcome for age-related macular degeneration

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Author	Yamashiro Kenji Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Sakyo, Kyoto, 606-8507, Japan Department of Ophthalmology, Otsu Red Cross Hospital, Otsu, Shiga, 520-8511, Japan Mori Keisuke Department of Ophthalmology, Saitama Medical University, Iruma, Saitama, 350-0495, Japan Department of Ophthalmology, International University of Health and Welfare, Nasu-Shiobara, Tochigi, 329-2763, Japan Honda Shigeru Department of Surgery, Division of Ophthalmology, Kobe University Graduate School of Medicine, Chuo, Kobe, 650-0017, Japan Kano Mariko Department of Ophthalmology, Fukushima Medical University School of Medicine, Fukushima, 960-1247, Japan Department of Ophthalmology, Tokyo Women’s Medical University, Yachiyo Medical Center, Chiba, 276-0046, Japan Yanagi Yasuo Department of Ophthalmology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo, Tokyo, 113-0033, Japan Ophthalmology and Visual Sciences Program, Duke-NUS Medical School, National University of Singapore, Singapore, 119077, Singapore Singapore National Eye Centre, Singapore Eye Research Institute, Singapore, 168751, Singapore Obana Akira Department of Ophthalmology, Seirei Hamamatsu General Hospital, Shizuoka, 430-8558, Japan Sakurada Yoichi Department of Ophthalmology, Faculty of Medicine, University of Yamanashi, Chuo, Yamanashi, 409-3898, Japan Sato Taku Department of Ophthalmology, Gunma University School of Medicine, Gunma, 371-0034, Japan Takasaki Sato Eye Clinic, Gunma, 370-0036, Japan Nagai Yoshimi Department of Ophthalmology, Kansai Medical University, Osaka, 573-1191, Japan Hikichi Taiichi Ohtsuka Eye Hospital, Sapporo, 001-0016, Japan Hikichi Eye Clinic, Sapporo, 060-0807, Japan Kataoka Yasushi Miyata Ophthalmic Hospital, Miyazaki, 885-0051, Japan Hara Chikako Department of Ophthalmology, Osaka University Graduate School of Medicine, Osaka, 565-0871, Japan KOYAMA, Yasuro Koizumi Hideki Department of Ophthalmology, Tokyo Women’s Medical University, School of Medicine, Tokyo, 162-8666, Japan Yoshikawa Munemitsu Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Sakyo, Kyoto, 606-8507, Japan Miyake Masahiro Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Sakyo, Kyoto, 606-8507, Japan Nakata Isao Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Sakyo, Kyoto, 606-8507, Japan Department of Ophthalmology, Otsu Red Cross Hospital, Otsu, Shiga, 520-8511, Japan Tsuchihashi Takashi Department of Ophthalmology, Saitama Medical University, Iruma, Saitama, 350-0495, Japan Horie-Inoue Kuniko Division of Gene Regulation and Signal Transduction, Research Center for Genomic Medicine, Saitama Medical University, Hidaka, Saitama, 350-1241, Japan Matsumiya Wataru Department of Surgery, Division of Ophthalmology, Kobe University Graduate School of Medicine, Chuo, Kobe, 650-0017, Japan Ogasawara Masashi Department of Ophthalmology, Fukushima Medical University School of Medicine, Fukushima, 960-1247, Japan Obata Ryo Department of Ophthalmology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo, Tokyo, 113-0033, Japan Yoneyama Seigo Department of Ophthalmology, Faculty of Medicine, University of Yamanashi, Chuo, Yamanashi, 409-3898, Japan Matsumoto Hidetaka Department of Ophthalmology, Gunma University School of Medicine, Gunma, 371-0034, Japan Ohnaka Masayuki Department of Ophthalmology, Kansai Medical University, Osaka, 573-1191, Japan Kitamei Hirokuni Ohtsuka Eye Hospital, Sapporo, 001-0016, Japan Sayanagi Kaori Hikichi Eye Clinic, Sapporo, 060-0807, Japan Ooto Sotaro Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Sakyo, Kyoto, 606-8507, Japan Tamura Hiroshi Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Sakyo, Kyoto, 606-8507, Japan Oishi Akio Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Sakyo, Kyoto, 606-8507, Japan Kabasawa Sho Department of Ophthalmology, Saitama Medical University, Iruma, Saitama, 350-0495, Japan Ueyama Kazuhiro Department of Ophthalmology, Saitama Medical University, Iruma, Saitama, 350-0495, Japan Miki Akiko Department of Surgery, Division of Ophthalmology, Kobe University Graduate School of Medicine, Chuo, Kobe, 650-0017, Japan Kondo Naoshi Department of Surgery, Division of Ophthalmology, Kobe University Graduate School of Medicine, Chuo, Kobe, 650-0017, Japan Bessho Hiroaki Department of Surgery, Division of Ophthalmology, Kobe University Graduate School of Medicine, Chuo, Kobe, 650-0017, Japan Saito Masaaki Department of Ophthalmology, Fukushima Medical University School of Medicine, Fukushima, 960-1247, Japan Department of Ophthalmology and Visual Sciences, Akita University Graduate School of Medicine, Akita, 010-8543, Japan Takahashi Hidenori Department of Ophthalmology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo, Tokyo, 113-0033, Japan Department of Ophthalmology, Jichi Medical University, Tochigi, 329-0498, Japan Tan Xue Department of Ophthalmology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo, Tokyo, 113-0033, Japan Azuma Keiko Department of Ophthalmology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo, Tokyo, 113-0033, Japan Kikushima Wataru Department of Ophthalmology, Faculty of Medicine, University of Yamanashi, Chuo, Yamanashi, 409-3898, Japan Mukai Ryo Ohira Akihiro Department of Ophthalmology, Shimane University Faculty of Medicine, Shimane, 693-0021, Japan Gomi Fumi Department of Ophthalmology, Osaka University Graduate School of Medicine, Osaka, 565-0871, Japan Department of Ophthalmology, Hyogo College of Medicine, Hyogo, 663-8501, Japan Miyata Kazunori Miyata Ophthalmic Hospital, Miyazaki, 885-0051, Japan Takahashi Kanji Department of Ophthalmology, Kansai Medical University, Osaka, 573-1191, Japan Kishi Shoji Department of Ophthalmology, Gunma University School of Medicine, Gunma, 371-0034, Japan Maebashi Central Eye Clinic, Gunma, 371-0031, Japan Iijima Hiroyuki Department of Ophthalmology, Faculty of Medicine, University of Yamanashi, Chuo, Yamanashi, 409-3898, Japan Sekiryu Tetsuju Department of Ophthalmology, Fukushima Medical University School of Medicine, Fukushima, 960-1247, Japan View author publications Iida Tomohiro Department of Ophthalmology, Tokyo Women’s Medical University, School of Medicine, Tokyo, 162-8666, Japan Awata Takuya Department of Diabetes, Endocrinology and Metabolism, International University of Health and Welfare Hospital, 537-3 Iguchi, Nasu-Shiobara, Tochigi, 329-2763, Japan Inoue Satoshi Division of Gene Regulation and Signal Transduction, Research Center for Genomic Medicine, Saitama Medical University, Hidaka, Saitama, 350-1241, Japan Yamada Ryo Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, 606-8507, Japan View author publ Matsuda Fumihiko Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, 606-8507, Japan Tsujikawa Akitaka Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Sakyo, Kyoto, 606-8507, Japan Department of Ophthalmology, Kagawa University Faculty of Medicine, Miki, Kagawa, 761-0793, Japan View author pu Negi Akira Department of Surgery, Division of Ophthalmology, Kobe University Graduate School of Medicine, Chuo, Kobe, 650-0017, Japan Yoneya Shin Department of Ophthalmology, Saitama Medical University, Iruma, Saitama, 350-0495, Japan View author Iwata Takeshi Division of Molecular and Cellular Biology, National Institute of Sensory Organs, National Hospital Organization Tokyo Medical Center, Tokyo, 152-8902, Japan Yoshimura Nagahisa Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Sakyo, Kyoto, 606-8507, Japan
Journal Title	SCIENTIFIC REPORTS
Volume	7
ISSN	2045-2322
Published Date	2017-08-23
DOI	10.1038/s41598-017-09632-0
PubMed ID	28835685
Publisher	NATURE PUBLISHING GROUP
NII Type	Journal Article
OAI-PMH Set	Faculty of Medicine
Remark	This work was supported by grant from the Ministry of Health, Labour and Welfare of Japan, Tokyo, Japan. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.