number of downloads : 136

Open Date : 2020-01-20
1.23 MB
Author
Description
Both the disruption of endothelial homeostasis and tissue fibrosis are characteristics of diabetic complications. Accumulating evidence has revealed the significant role of vascular endothelial cells in tissue fibrogenesis via endothelial-mesenchymal transition (EndMT).
We have recently focused on the overexpression of endothelial dipeptidyl peptidase (DPP)-4, a critical pathological feature of the molecular mechanisms of EndMT, and suggest that DPP-4 inhibitors have great therapeutic potential via their antifibrotic effects. However, the diverse pleiotropic effects of DPP-4, both its enzyme-dependent and enzyme-independent effects, can be detrimental in some cases. This review provides an update on the biology of DPP-4, a profibrotic molecule, in addition to a discussion of cancer biology.
Subject
fibrosis
microRNA
integrin
extracellular matrix
cancer
Journal information
Shimane Journal of Medical Science 36 ( 2-3 ), 33 - 40 , 2019-12
Publisher
Faculty of Medicine, Shimane University
Rights
Faculty of Medicine, Shimane University
他の一覧
このエントリーをはてなブックマークに追加