Author | |
Description | Both the disruption of endothelial homeostasis and tissue fibrosis are characteristics of diabetic complications. Accumulating evidence has revealed the significant role of vascular endothelial cells in tissue fibrogenesis via endothelial-mesenchymal transition (EndMT).
We have recently focused on the overexpression of endothelial dipeptidyl peptidase (DPP)-4, a critical pathological feature of the molecular mechanisms of EndMT, and suggest that DPP-4 inhibitors have great therapeutic potential via their antifibrotic effects. However, the diverse pleiotropic effects of DPP-4, both its enzyme-dependent and enzyme-independent effects, can be detrimental in some cases. This review provides an update on the biology of DPP-4, a profibrotic molecule, in addition to a discussion of cancer biology. |
Subject | fibrosis
microRNA
integrin
extracellular matrix
cancer
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Journal information |
Shimane Journal of Medical Science
36
( 2-3
), 33
- 40
, 2019-12
|
Publisher | Faculty of Medicine, Shimane University
|
Rights | Faculty of Medicine, Shimane University
|