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language |
eng
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Description | Objective: The aim of this study is to clarify the effect of pioglitazone on serum Dipeptidyl peptidase-4 (DPP-4) level in type 2 diabetes mellitus.
Methods: Chronological changes in serum DPP-4 level were observed in 22 patients treated with pioglitazone and 15 with metformin during 12 months. Serum DPP-4 concentrations were measured by an ELISA kit. Results: In the pioglitazone group, serum DPP-4 levels were significantly increased from baseline (774 ± 198 ng/mL) with mean changes of 53 mg/mL [6.8% increase, 95% confidence interval (CI) 2 to 104, p<0.05] after 3 months and of 74 mg/mL (9.4% increase, 95% CI 21 to 126, p<0.01) after 12 months. On the other hand, serum DPP-4 levels were not changed in the metformin group. Percent change in serum DPP-4 level was significantly and positively correlated with percent change in body mass index (r=0.39, p<0.02). The association was still significant even after adjusting for age, duration of diabetes, serum creatinine, and HbAc1 (β=0.59, p<0.02).
Conclusion: The present study showed that pioglitazone, but not metformin, chronologically increased serum DPP-4 levels during 12 months.
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Subject | Pioglitazone
Dipeptidyl Peptidase-4
Type 2 diabetes mellitus
Adipocyte
PPAR-γ
PPAR-γAgonist
Metformin
Body Mass Index
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Journal Title |
Journal of diabetes & metabolism
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Volume | 5
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Issue | 8
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Start Page | 1000416
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ISSN | 21556156
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Published Date | 2014-08
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DOI | |
Publisher | OMICS International
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NII Type |
Journal Article
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Format |
PDF
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Rights | © 2014 Kanazawa I, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Text Version |
出版社版
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Gyoseki ID | e26807
e26992
e27525
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OAI-PMH Set |
Faculty of Medicine
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