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language
eng
Author
Esrat Jahan Department of Developmental Biology, Faculty of Medicine, Shimane University, Izumo-shi 693-8501, Shimane, Japan
Ashiq Mahmood Rafiq Department of Developmental Biology, Faculty of Medicine, Shimane University, Izumo-shi 693-8501, Shimane, Japan
Description
Until recently, fetal surgery was only used for fetuses with very poor prognosis who were likely to die without intervention. With advances in imaging, endoscopic techniques, anesthesia and novel interventions, fetal surgery is becoming a realistic option for conditions with less severe prognoses, where the aim is now to improve quality of life rather than simply allow survival. Until forty years ago, the uterus shielded the fetus from observation and therapy. Rapid changes in the diagnosis and treatment of human fetal anatomical abnormalities are due to improved fetal imaging studies, fetal sampling techniques (e.g., amniocentesis and chorionic villus sampling), and a better understanding of fetal pathophysiology derived from laboratory animals. Fetal therapy is the logical culmination of progress in fetal diagnosis. In other words, the fetus is now a patient. Now-a-days, in utero (IU) and exo utero (EU) surgical methods are popular for experimental analyses of the histogenesis of organ development. Using these surgical methods, developmental anomalies can be created and then repaired. By applying microinjection and/or fetal surgery with these methods, models of developmental anomalies such as neural tube defects, temporomandibular joint defects, hip joint defects, digit amputation, limb and digit development and regeneration, and tooth germ transplantation in the jaw could be created and later observed. After observing different types of anomalies, novel IU and EU surgical techniques would be the best approach for repairing or treating those anomalies or diseases. This review will focus on the rationale for the IU and EU creation of animal models of different organ defects or anomalies and their repair, based on analyses of organ histogenesis and pathologic observations. It will also focus in detail on the surgical techniques of both IU and EU methods.
Subject
Myelomeningocele
Microinjection
Rodent
Sheep
Neural tube defect
Temporomandibular joint
Fetal surgery
In utero
Exo utero
Journal Title
World Journal of Surgical Procedures
Volume
5
Issue
2
Start Page
198
End Page
207
Published Date
2015-7-28
DOI
Publisher
Baishideng Publishing Group Inc
NII Type
Journal Article
Format
PDF
Relation
Text Version
出版社版
Gyoseki ID
e28706
OAI-PMH Set
Faculty of Medicine
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