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Title Transcription
カルシトニン トウヨ ガ メンヨウ ノ ニョウチュウ カルシウム オヨビ リン ハイセツ ニ オヨボス エイキョウ
Title Alternative (English)
Effects of Calcitonin Administration on Urinary Calcium and Phosphorus Excretion in Sheep
File
language
eng
Author
Matsui, Tohru
Yano, Hideo
Kawashima, Ryoji
Description
The objective of this experiment is to investigate roles of calcitonin on urinary calcium and phosphorus excretion in sheep. Three thyroidectomized wethers were injected with 0 (vehicle), 0.25, 0.5 and 1 U/kg body weight of porcine calcitonin and three sham operated sheep were injected with vehicle. Serum calcium and phosphorus concentrations were decreased by calcitonin administration. And serum parathyroid hormone concentration was increased along with the reduction of serum calcium concentration. Urinary volume was more in thyroidectomized sheep than in sham operated ones and tended to be decreased by calcitonin administration though the reduction of urinary volume was not dose dependent. Urinary calcium excretion was more in thyroidectomized sheep than in sham operated ones. Though the smallest does of calcitonin decreased calcium excretion in urine, the largest dose increased urinary calcium excretion in thyroidectomized sheep. Urinary phosphorus excretion was much less in thyroidectomized animals than in sham operated ones. Calcitonin administration increased phosphorus excretion in dose dependent manner in thyroidectomized sheep. However any doses of calcitonin could not recover phosphorus excretion to the level of sham operated sheep. These results suggested that calcitonin commonly decreased urinary calcium excretion for the conservation of calcium, while a high concentration of blood calcitonin increased urinary calcium excretion which promotes the hypocalcemic action of calcitonin. And it was confirmed that calcitonin had a hyperphosphaturic action in sheep.
Journal Title
Bulletin of the Faculty of Agriculture, Shimane University
Volume
23
Start Page
204
End Page
208
ISSN
0370940X
Published Date
1989-12-21
NCID
AN00108015
Publisher
島根大学農学部
Publisher Aalternative
Shimane University, Faculty of Agriculture
NII Type
Departmental Bulletin Paper
OAI-PMH Set
Faculty of Life and Environmental Science
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