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File
language
eng
Author
Masaki, Yoji
Tanigawa, Keiichiro
Oguni, Satoshi
Tsuchiyama, Shinichi
Note, Shinya
Description
The effects of hypoglycemic sulfonylurea gliclazide on insulin release and its interaction with tumor-promoting phorbol ester in rat pancreatic islets were examined. Lower concentrations of gliclazide stimulated insulin release in the presence of 5.6mM glucose, but the addition of high concentrations of gliclazide resulted in a tendency to reduce insulin release. The stimulatory action of gliclazide on insulin release was abolished in the absence of Ca^<2+>. Gliclazide also failed to stimulate insulin release in the presence of 16.7mM glucose, and 50μM gliclazide inhibited insulin release significantly. A synergistic effect of gliclazide on insulin release was observed in the presence of phorbol ester 12-O-tetradecanoyl-phorbol-13-acetate (TPA). Such a combined effect of gliclazide with TPA was inhibited when extracellular Ca^<2+> was not present. These results indicate that gliclazide stimulates insulin release to affect Ca^<2+> handling in the pancreatic B cell.
Subject
Sulfonylurea
insulin release
phorbol ester
Journal Title
Shimane journal of medical science
Volume
10
Issue
1
Start Page
1
End Page
8
ISSN
03865959
ISSN(Online)
24332410
Published Date
1986-09-01
NCID
AA00841586
Publisher Aalternative
Shimane Medical University
NII Type
Departmental Bulletin Paper
Format
PDF
Text Version
出版社版
OAI-PMH Set
Faculty of Medicine
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