number of downloads : ?
Title Transcription
クロロフォルム チュウドクセイ カンショウガイ ノ ジッケンテキ ケンキュウ 5 : ニンシン コウキ カト ノ クロロフォルム カンショウガイ
Title Alternative (English)
An Experimental Study on Chloroform-toxic Liver Disturbance : V. Chloroform Hepatic Injury in Late Pregnant Rabbit
language
jpn
Author
Sakamoto, Iwao
Iida, Kouji
Murao, Fuminori
Description
To lnduce liver injury, the late pregnant rabbits were administered chloroform 0.5ml/kg body weight, subcutaneously twice at intervals of 48 hours.They were sacrificed 48 hours after the final administration of chloroform. These histological findings of the liver were compared with hepatic injurg of non-pregnant rabbits induced by chloroform in the same way. Hydropie degeneration, acidophilic degeneration and eosinophilic coagulative necrosis are the common response of the liver to chloroform poisoning These leslons were decreased in late pregnant rabbits as compared with non-pregnant rabbits, but central fatty degeneration was significantly increased in late pregnant rabblts. Tne size of fat droplet in these hepatic cells were small to medium and the deposition of fat in the lobul were central to peripheral zone. These histological appearances were quite like as the diagnosis of acute fatty liver in late human pregnancy, and it seems to suggest that the pathogenesis of fatty degeneration may be related to the specific fatty metabolism in late pregnancy.
Subject
chloroform
肝障害
妊娠
hepatic injury
pregnancy
Journal Title
Bulletin of Shimane Medical University
Volume
11
Start Page
45
End Page
51
ISSN
03879097
Published Date
1988-12-01
NCID
AN00107602
Publisher
島根医科大学
NII Type
Departmental Bulletin Paper
Format
PDF
Text Version
出版社版
OAI-PMH Set
Faculty of Medicine
他の一覧
このエントリーをはてなブックマークに追加