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language
eng
Author
Ichinose, Mitsuyuki
Hirota, Akihiko
Description
The immunomodulatory effects of both acute and chronic alcohol use/treatment have been presumed, because chronic alcoholism increases susceptibility to bacterial infections such as pneumonia and tuberculosis. In the present study, the effects of ethanol on phagocytosis of mouse peritoneal macrophages were examined by means of fluorescent particles and flow cytometry. Phagocytosis of latex beads, zymosan (Saccharomyces cerevisiae, S. cerevisiae) and Staphylococcus aureus (S. aureus) was suppressed by ethanol in a dose-dependent manner. The results suggest that the reduced function of macrophages, at least in part, accounts for an increased susceptibility of alcoholic patients to infection.
Subject
macrophage
phagocytosis
ethanol
Journal Title
Bulletin of Shimane Medical University
Volume
20
Start Page
43
End Page
46
ISSN
03879097
Published Date
1997-12-01
NCID
AN00107602
Publisher
島根医科大学
NII Type
Departmental Bulletin Paper
Format
PDF
Text Version
出版社版
OAI-PMH Set
Faculty of Medicine
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