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Title Alternative (English)
The Effect of Intravenous Lidocaine on the Response of Medullary Inspiratory Neurons to CO_2 in Cats
File
language
eng
Author
Kasaba, Toshiharu
Kosaka, Yoshihiro
Description
The effect of intravenous lidocaine on the response of medullary inspiratory neurons to CO_2 was studied in 11 urethane-anesthetized ventilated cats. Lidocaine was administrated at a subconvulsive dose through a venous cannula by means of a constant-rate infusion pump (0.3-0.5mg・kg^<-1>・min^<-1>). We compared the number of spikes before and after CO_2 administration in a lidocaine-free state. Then, we likewise compared the number of spikes before and after CO_2 administration in a lidocaine administered-state. The rate of increase of spikes per mmHg of PaCO_2 was 1.49±0.72 spike・mmHg^<-1> in the control lidocaine-free group, and 0.96±0.51 spike・mmHg^<-1> in the lidocaine-administered group. The response to CO_2 was significantly suppressed in the lidocaine group (p<0.05). These results suggest that systemic lidocaine suppresses respiratory center in the urethane-anesthetized cats.
Subject
carbon dioxide
cats
lidocaine
Journal Title
Shimane journal of medical science
Volume
12
Start Page
23
End Page
30
ISSN
03865959
ISSN(Online)
24332410
Published Date
1990
NCID
AA00841586
Publisher Aalternative
Shimane Medical University
NII Type
Departmental Bulletin Paper
Format
PDF
Text Version
出版社版
OAI-PMH Set
Faculty of Medicine
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