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language
eng
Author
Shinji, 99665240
Shirakawa, Hiroki
Ishibe, Tomoyuki
Kadena, Hitoshi
Usui, Tsuguru
Description
A total of 16 patients with muscle invasive bladder cancer, clinical stage T2N0M0 (6), T3aN0M0 (7) or T3bN0M0 (3), underwent 1 to 4 cycles of neoadjuvant cisplatin-based chemotherapy followed by either partial cystectomy or transurethral resection. The overall response rate to the chemotherapy was 56% (95% confidence limits 32 to 79%). For the stages T2 and T3a cancer patients the overall response rate was 69%, while all 3 patients with T3b cancer showed incomplete response. Ten (63%) of 16 patients relapsed. Recurrence of superficial bladder cancer was observed in 5 patients with T2G2-3 or T3aG2 tumors, whereas invasive bladder cancer or metastases developed in 5 patients with T3a-3bG3 tumors. Eleven (69%) patients are alive with a functional bladder at a median followup of 48 months+. While bladder preservation may be permitted in selected patients with T2-3a disease, it is inconclusive whether neoadjuvant chemotherapy improves the survival of patients with invasive bladder cancer.
Subject
Neoadjuvant chemotherapy
Bladder cancer
Bladder preservation
Journal Title
Shimane journal of medical science
Volume
14
Start Page
15
End Page
17
ISSN
03865959
ISSN(Online)
24332410
Published Date
1996
NCID
AA00841586
Publisher Aalternative
Shimane Medical University
NII Type
Departmental Bulletin Paper
Format
PDF
Text Version
出版社版
Gyoseki ID
e28121
e28133
OAI-PMH Set
Faculty of Medicine
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