File
language
eng
Attribute
original article
Author
Mu, Qingchun
Udagawa, Jun
Sun, Tao
Description
 Leptin is detected in sera and leptin receptors are expressed in the cerebellum of mouse embryos,suggesting roles of leptin in the cerebellar development. We here injected leptin into the lateral cerebralventricle of leptin receptor-deficient db/db and wild-type mouse embryos and examined the effects on cerebellar development. Leptin was injected on embryonic day(E)14, and the embryos were let to develop by exo utero method till E16 when the cerebellum was examined. Cerebellar volume, number of Math1-immunopositive progenitor cells of granule cells in the external germinal cell layer(EGL)did not differ significantly between db/db and wildtype. However, calbindin-positive Purkinje cells in the Purkinje cell layer(PCL)of db/db tended to be fewer in number and appeared less differentiated than those in wild-type. These results suggest that leptin may not have effect on EGL cells but may promote migration and/or differentiation of progenitors of Purkinje cells in PCL.
Journal Title
Shimane journal of medical science
Volume
27
Start Page
1
End Page
7
ISSN
03865959
ISSN(Online)
24332410
Published Date
2010-12-01
NCID
AA00841586
Publisher Aalternative
Shimane University Faculty of Medicine
NII Type
Departmental Bulletin Paper
Format
PDF
Text Version
出版社版
OAI-PMH Set
Faculty of Medicine
Remark
http://ci.nii.ac.jp/vol_issue/nels/AA00841586_jp.html