File
language
eng
Attribute
Original article
Author
Kagohashi, Yukiko
Naora, Hiroyuki
Description
Some biological response modifiers (BRMs) have been shown to suppress teratogenesis. We previously showed that PSK, a BRM and a protein-bound polysaccharide extracted from Basidiomycetes, suppressed X-irradiation-induced ocular anomalies in mouse embryos.
In those studies, we noticed that the irradiated and PSK-treated embryos tended to be smaller in body size than the controls that were irradiated but not treated with PSK, in spite of the reduced teratogenesis. In this study, therefore, we analyzed in detail systemic development from embryonic day (E)7.75 to E9.0 of embryos that were irradiated and treated with PSK at E7.5, following the same experimental protocol used in the previous study. PSK treatment not only enhanced the X-irradiationinduced developmental delay, but also delayed development, albeit less extensively, as compared with controls. These developmentally delayed embryos generally showed proportional and symmetric size reduction. Possible mechanisms of the PSK-induced delay in systemic development and a relation with its anti-teratogenic effect are discussed.
Journal Title
Shimane journal of medical science
Volume
20
Issue
2
Start Page
25
End Page
29
ISSN
03865959
ISSN(Online)
24332410
Published Date
2002-12-01
NCID
AA00841586
Publisher Aalternative
Shimane Medical University
NII Type
Departmental Bulletin Paper
Format
PDF
Text Version
出版社版
OAI-PMH Set
Faculty of Medicine
Remark
http://ci.nii.ac.jp/vol_issue/nels/AA00841586_jp.html