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TAKENAGA Keizo

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Reactive Oxygen Species-generating Mitochondrial DNA Mutation Up-regulates Hypoxia-inducible Factor-1 alpha Gene Transcription via Phosphatidylinositol 3-Kinase-Akt/Protein Kinase C/Histone Deacetylase Pathway

Creator	Koshikawa Nobuko \| Hayashi Jun-Ichi \| Nakagawara Akira \| Takenaga Keizo
Journal	JOURNAL OF BIOLOGICAL CHEMISTRY Volume 284 Issue 48 pp. 33185 - 33194
Date of Issued	published_at 2009-11-27

The innate immune system in host mice targets cells with allogenic mitochondrial DNA

Creator	Ishikawa Kaori \| Toyama-Sorimachi Noriko \| Nakada Kazuto \| Morimoto Mami \| Imanishi Hirotake \| Yoshizaki Mariko \| Sasawatari Shigemi \| Niikura Mamoru \| Takenaga Keizo \| Yonekawa Hiromichi \| Hayashi Jun-Ichi
Journal	JOURNAL OF EXPERIMENTAL MEDICINE Volume 207 Issue 11 pp. 2297 - 2305
Date of Issued	published_at 2010-10-25

Mitochondrial DNA Mutations Regulate Metastasis of Human Breast Cancer Cells

Creator	Imanishi Hirotake \| Hattori Keisuke \| Wada Reiko \| Ishikawa Kaori \| Fukuda Sayaka \| Takenaga Keizo \| Nakada Kazuto \| Hayashi Jun-Ichi
Journal	PLOS ONE Volume 6 Issue 8
Date of Issued	published_at 2011-08-11

Hydrogen Sulfide Inhibits Hypoxia- But Not Anoxia-Induced Hypoxia-Inducible Factor 1 Activation in a von Hippel-Lindau- and Mitochondria-Dependent Manner

Creator	Kai Shinichi \| Tanaka Tomoharu \| Daijo Hiroki \| Harada Hiroshi \| Kishimoto Shun \| Suzuki Kengo \| Takabuchi Satoshi \| Takenaga Keizo \| Fukuda Kazuhiko \| Hirota Kiichi
Journal	ANTIOXIDANTS & REDOX SIGNALING Volume 16 Issue 3 pp. 203 - 216
Date of Issued	published_at 2012-02

Specific mtDNA Mutations in Mouse Carcinoma Cells Suppress Their Tumor Formation via Activation of the Host Innate Immune System

Creator	Imanishi Hirotake \| Takibuchi Gaku \| Kobayashi Toshihiko \| Ishikawa Kaori \| Nakada Kazuto \| Mori Masayuki \| Kikkawa Yoshiaki \| Takenaga Keizo \| Toyama-Sorimachi Noriko \| Hayashi Jun-Ichi
Journal	PLOS ONE Volume 8 Issue 9
Date of Issued	published_at 2013-09-30

Polymorphic mutations in mouse mitochondrial DNA regulate a tumor phenotype

Creator	Takibuchi Gaku \| Imanishi Hirotake \| Morimoto Mami \| Ishikawa Kaori \| Nakada Kazuto \| Toyama-Sorimachi Noriko \| Kikkawa Yoshiaki \| Takenaga Keizo \| Hayashi Jun-Ichi
Journal	MITOCHONDRION Volume 13 Issue 6 pp. 881 - 887
Date of Issued	published_at 2013-11

Silencing of S100A4, a metastasis-associated protein, in endothelial cells inhibits tumor angiogenesis and growth

Creator	Ochiya Takahiro \| Takenaga Keizo \| Endo Hideya
Journal	ANGIOGENESIS Volume 17 Issue 1 pp. 17 - 26
Date of Issued	published_at 2014-01

Transmitochondrial mice as models for primary prevention of diseases caused by mutation in the tRNA(Lys) gene

Creator	Shimizu Akinori \| Mito Takayuki \| Hayashi Chisato \| Ogasawara Emi \| Koba Ryusuke \| Negishi Issei \| Takenaga Keizo \| Nakada Kazuto \| Hayashi Jun-Ichi
Journal	PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA Volume 111 Issue 8 pp. 3104 - 3109
Date of Issued	published_at 2014-02-25

Efficient inhibition of tumor angiogenesis and growth by a synthetic peptide blocking S100A4-methionine aminopeptidase 2 interaction

Creator	Ochiya Takahiro \| Takenaga Keizo \| Asagiri Masataka \| Nakano Kazumi \| Satoh Hitoshi \| Watanabe Toshiki \| Imajoh-Ohmi Shinobu \| Endo Hideya
Journal	MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT Volume 2
Date of Issued	published_at 2015

Anticancer Effect of Ginger Extract against Pancreatic Cancer Cells Mainly through Reactive Oxygen Species-Mediated Autotic Cell Death

Creator	Akimoto Miho \| Iizuka Mari \| Kanematsu Rie \| Yoshida Masato \| Takenaga Keizo
Journal	PLOS ONE Volume 10 Issue 5
Date of Issued	published_at 2015-05-11

The antioxidant N-acetyl cysteine suppresses lidocaine-induced intracellular reactive oxygen species production and cell death in neuronal SH-SY5Y cells

Creator	Okamoto Akihisa \| Tanaka Masahiro \| Sumi Chisato \| Oku Kanako \| Kusunoki Munenori \| Nishi Kenichiro \| Matsuo Yoshiyuki \| Takenaga Keizo \| Shingu Koh \| Hirota Kiichi
Journal	BMC ANESTHESIOLOGY Volume 16
Date of Issued	published_at 2016-10-24

Soluble IL-33 receptor sST2 inhibits colorectal cancer malignant growth by modifying the tumour microenvironment

Creator	Akimoto Miho \| Maruyama Riruke \| Takamaru Hiroyuki \| Ochiya Takahiro \| Takenaga Keizo
Journal	NATURE COMMUNICATIONS Volume 7
Date of Issued	published_at 2016-11-24

HIF-1-mediated suppression of mitochondria electron transport chain function confers resistance to lidocaine-induced cell death

Creator	Okamoto Akihisa \| Sumi Chisato \| Tanaka Hiromasa \| Kusunoki Munenori \| Iwai Teppei \| Nishi Kenichiro \| Matsuo Yoshiyuki \| Harada Hiroshi \| Takenaga Keizo \| Bono Hidemasa \| Hirota Kiichi
Journal	SCIENTIFIC REPORTS Volume 7
Date of Issued	published_at 2017-06-19

Cytoplasmic transfer of heritable elements other than mtDNA from SAMP1 mice into mouse tumor cells suppresses their ability to form tumors in C57BL6 mice

Creator	Shimizu Akinori \| Tani Haruna \| Takibuchi Gaku \| Ishikawa Kaori \| Sakurazawa Ryota \| Inoue Takafumi \| Hashimoto Tetsuo \| Nakada Kazuto \| Takenaga Keizo \| Hayashi Jun-Ichi
Journal	BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS Volume 493 Issue 1 pp. 252 - 257
Date of Issued	published_at 2017-11-4

Association of predicted pathogenic mutations in mitochondrial ND genes with distant metastasis in NSCLC and colon cancer

Creator	Koshikawa Nobuko \| Akimoto Miho \| Hayashi Jun-Ichi \| Nagase Hiroki \| Takenaga Keizo
Journal	SCIENTIFIC REPORTS Volume 7
Date of Issued	published_at 2017-11-14

HIF-2α dictates the susceptibility of pancreatic cancer cells to TRAIL by regulating survivin expression

Creator	Harashima Nanae \| Takenaga Keizo \| Akimoto Miho \| Harada Mamoru
Journal	Oncotarget Volume 8 pp. 42887 - 42900
Date of Issued	published_at 2017-04-17