Effects of zinc on immune response and ascorbic acid status in alcoholics

Shimane journal of medical science Volume 21 Issue 2 Page 19-24 published_at 2003-09-01
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Title
Effects of zinc on immune response and ascorbic acid status in alcoholics
Creator
Chakrabarti Moitrayee
Chakrabarti Asim
Bandyopadhyay Asok
Chakravarti Asirn K.
Source Title
Shimane journal of medical science
Volume 21
Issue 2
Start Page 19
End Page 24
Journal Identifire
ISSN 03865959
EISSN 24332410
Descriptions
The possible effect of zinc as a detoxicant and an immunostimulant has been evaluated by supplementing chronic alcoholics without overt liver disease with oral zinc sulphate. Satisfactory changes were observed after the supplementation and many of the altered features of the alcoholics showed tendency towards normalcy. After the therapy there was a reduction in serum γ-glutamyl transpeptidase activity, increase in the percentage of serum albumin, rosette forming cells, blastogenesis and DNA synthesis in proliferating T cells. On the other hand there was decrease in the level of serum immunoglobulin and both plasma and leucocyte dehydroascorbic acid. It seems that both blastogenesis and the increased rate of DNA synthesis in alcoholics after zinc therapy could be a direct effect of zinc or its action may be mediated by ascorbate /dehydroascorbate system through its antioxidant property.
Language
eng
Resource Type departmental bulletin paper
Publisher
Shimane Medical University
Date of Issued 2003-09-01
Publish Type Version of Record
Access Rights open access
Relation
[NCID] AA00841586
Remark http://ci.nii.ac.jp/vol_issue/nels/AA00841586_jp.html