Possible mechanism of hypothermia induced bu serum of a hypothermic patient in restrained rats

Shimane journal of medical science Volume 22 Issue 1 Page 7-11 published_at 2005-03-01
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Title
Possible mechanism of hypothermia induced bu serum of a hypothermic patient in restrained rats
Creator
Sugimoto Naotoshi
Asai Akira
Maruyama Megumi
Koizumi Shoichi
Source Title
Shimane journal of medical science
Volume 22
Issue 1
Start Page 7
End Page 11
Journal Identifire
ISSN 03865959
EISSN 24332410
Descriptions
We experienced a patient who suffered from severe hypothermia. The etiology and mechanism of hypothermia were not known. Intraperitoneal (i.p.) injections of the patient's serum into restrained rats produced a significant hypothermia without associated changes in tail skin temperature. Heat balance of rats was then measured with direct and indirect calorimetry before and during the i.p. injection of the patient serum. The hypothermia induced by the patient's serum was associated with a reduction of oxygen consumption, but was not accompanied by changes in evaporative and nonevaporative heat loss. The results suggest that cryogenic substance(s), which was excessively produced in patient's blood, may affect thermogenic function and then produce hypothermia in rats.
Language
eng
Resource Type departmental bulletin paper
Publisher
Shimane University Faculty of Medicine
Date of Issued 2005-03-01
Publish Type Version of Record
Access Rights open access
Relation
[NCID] AA00841586
Remark http://ci.nii.ac.jp/vol_issue/nels/AA00841586_jp.html