| ファイル情報(添付) | |
| タイトル ( eng ) |
How Genetic Polymorphisms Shape DNA Clearance and Inflammation In Vivo
|
| 著者 |
EHASAN Ahmmed Ameemul
MD TANVIR Rahman
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| 収録物名 |
Shimane Journal of Medical Science
|
| 巻 | 43 |
| 号 | 1-2 |
| 開始ページ | 1 |
| 終了ページ | 5 |
| 収録物識別子 |
ISSN 03865959
EISSN 24332410
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| 内容記述 |
抄録・要旨
Self-DNA must be efficiently cleared from extracellular spaces, lysosomes, and the cytosol to prevent activation of innate immune sensors such as TLR9 and cGAS–STING. Genetic polymorphisms in nucleases including dnase1, dnase1l3, dnase2 and trex1 impair DNA degradation by reducing catalytic activity, secretion, stability, or expression. These defects allow accumulation of immunostimulatory DNA in vivo, promoting type I interferon production, autoantibody formation, and inflammatory diseases. This mini review summarizes key nuclease variants across cellular compartments and their impact on DNA metabolism and immunity.
|
| 主題 |
dnase1
dnase1l3
dnase2
trex1
cGAS– STING pathway
TLR9
|
| 言語 |
英語
|
| 資源タイプ | 紀要論文 |
| 出版者 |
Faculty of Medicine, Shimane University
島根大学医学部
Shimane University Faculty of Medicine
|
| 発行日 | 2026-06 |
| 権利情報 |
Faculty of Medicine, Shimane University
|
| 権利関係（リンク） |  This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. |
| 出版タイプ | Version of Record（出版社版。早期公開を含む） |
| アクセス権 | オープンアクセス |
| 関連情報 |
[NCID]
AA00841586
|
