The Clinical Features and Treatment Outcomes of Intracranial Hemorrhage With Acute Leukemia and Disseminated Intravascular Coagulation

アクセス数 : 0
ダウンロード数 : 0

今月のアクセス数 : 0
今月のダウンロード数 : 0
ファイル情報(添付)
タイトル ( eng )
The Clinical Features and Treatment Outcomes of Intracranial Hemorrhage With Acute Leukemia and Disseminated Intravascular Coagulation
著者
河野 徳明
池添 隆之
和田 英夫
下之段 秀美
瀧川 健
栃木 太郎
仲池 隆史
山下 清
真柴 晃一
菊池 郁夫
落合 秀信
収録物名
Shimane Journal of Medical Science
41
4
開始ページ 109
終了ページ 117
収録物識別子
ISSN 03865959
EISSN 24332410
内容記述
抄録・要旨
Although intracranial hemorrhage (ICH)-complicating leukemia is life-threatening, its clinical features remain unclear due to the limited number of previous reports. In a retrospective study of 16 patients with hematological malignancy complicated by disseminated intravascular coagulation (DIC), including three patients with ICH, from 2018 to 2021 in Miyazaki Prefectural Miyazaki Hospital, we analyzed clinical features, laboratory markers, and treatment outcomes. The cumulative incidence of ICH was 18.7% and all patients presented with leukocytosis and DIC. Surprisingly, two patients died within a day due to ICH with brain herniation. One patient with ICH achieved complete remission. Notably, clinical markers showing higher leukocyte counts, higher LDH, higher FDP/d-dimer, higher HMGB-1, and poorer overall survival were identified in patients with leukemia with ICH. In conclusion, ICH should be considered a severe complication of hematological malignancies. Furthermore, the leukocyte count, and LDH and HMGB-1 levels may be related to leukemia with ICH.
主題
coma
intracranial hemorrhage
hematological malignancy with DIC
leukocytosis
circulating intranuclear proteins
HMGB-1
言語
英語
資源タイプ 紀要論文
出版者
Faculty of Medicine, Shimane University
島根大学医学部
Faculty of Medicine, Shimane University
Shimane University Faculty of Medicine
発行日 2024-12
権利情報
Faculty of Medicine, Shimane University
権利関係(リンク) Creative Commons License
This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
出版タイプ Version of Record(出版社版。早期公開を含む)
アクセス権 オープンアクセス
関連情報
[NCID] AA00841586