| File | |
| Title |
Aerobic Oxidative C–H Azolation of Indoles and One-Pot Synthesis of Azolyl Thioindoles by Flavin–Iodine-Coupled Organocatalysis
|
| Creator |
Tanimoto Kazumasa
Okai Hayaki
Oka Marina
Ohkado Ryoma
|
| Source Title |
Organic Letters
|
| Volume | 23 |
| Issue | 6 |
| Start Page | 2084 |
| End Page | 2088 |
| Journal Identifire |
ISSN 1523-7060
EISSN 1523-7052
|
| Descriptions |
The aerobic oxidative cross-coupling of indoles with azoles driven by flavin-iodine-coupled organocatalysis has been developed for the green synthesis of 2-(azol-1-yl)indoles. The coupled organocatalytic system enabled the one-pot three-component synthesis of 2-azolyl-3-thioindoles from indoles, azoles, and thiols in an atom-economical manner by utilizing molecular oxygen as the only sacrificial reagent.
|
| Subjects |
Oxidation reactions
Flavins
Chemical synthesis,Indoles
Cross coupling reaction
|
| Language |
eng
|
| Resource Type | journal article |
| Publisher |
American Chemical Society
|
| Date of Issued | 2021-03-19 |
| Publish Type | Accepted Manuscript |
| Access Rights | open access |
| Relation |
[DOI] 10.1021/acs.orglett.1c00241
|
