KN3014, a piperidine-containing small compound, inhibits auto-secretion of IL-1 beta from PBMCs in a patient with Muckle-Wells syndrome

SCIENTIFIC REPORTS Volume 10 Issue 1 published_at 2020-08-11
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Title
KN3014, a piperidine-containing small compound, inhibits auto-secretion of IL-1 beta from PBMCs in a patient with Muckle-Wells syndrome
Creator
Kaneko Naoe
Kurata Mie
Yamamoto Toshihiro
Shigemura Tomonari
Agematsu Kazunaga
Yamazaki Takashi
Takeda Hiroyuki
Sawasaki Tatsuya
Koga Tomohiro
Kawakami Atsushi
Yachie Akihiro
Migita Kiyoshi
Yoshiura Koh-ichiro
Masumoto Junya
Source Title
SCIENTIFIC REPORTS
Volume 10
Issue 1
Journal Identifire
ISSN 2045-2322
Language
eng
Resource Type journal article
Publisher
NATURE PUBLISHING GROUP
Date of Issued 2020-08-11
Access Rights metadata only access
Relation
[DOI] 10.1038/s41598-020-70513-0
[PMID] 32782316
Remark We thank the Division of Laboratory Animal Research of the Advanced Research Support Center (ADRES), Ehime University for technical assistance. This work was supported by JSPS KAKENHI, Grant Numbers JP17H04656 and JP17K19685 (to J.M.), and JP16H00609, JP17H00599, and JP18H00464 (to N.K.), and by the Center for Clinical and Translational Research of Kyushu University Hospital. This work was also supported by Platform for Drug Discovery, Informatics, and Structural Life Science from Japan Agency for Medical Research and Development (AMED).