Retrospective Analysis of Argatroban in 353 Patients with Acute Noncardioembolic Stroke

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We studied prognosis in 353 acute stokes patients treated by argatroban in comparison with 160 control group with ozagrel in our hospital. They were examined as to their stroke types, neurological severity according to the NIH Stroke Scale (NIHSS) and clinical outcomes on discharge by the modified Rankin Scale (mRS). Acute noncardioembolic stroke patients including lacunar infarction and atherothrombotic infarction showed functional recovery by argatroban, but the effectiveness of argatroban was not superior to ozagrel therapy defined by control group. Both of argatroban and ozagrel in atherothrombotic infarction showed improved by 1 points. We also could not find any significant difference between argatroban and ozagrel in each two stroke subtypes, lacunar infarction and atherothrombotic infarction.