Reduced muscle mass and accumulation of visceral fat are independently associated with increased arterial stiffness in postmenopausal women with type 2 diabetes mellitus

Diabetes research and clinical practice 122 巻 141-147 頁 2016-12 発行
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タイトル
Reduced muscle mass and accumulation of visceral fat are independently associated with increased arterial stiffness in postmenopausal women with type 2 diabetes mellitus
著者
収録物名
Diabetes research and clinical practice
122
開始ページ 141
終了ページ 147
収録物識別子
ISSN 01688227
内容記述
その他
BACKGROUND: Several studies showed that sarcopenia and visceral obesity are associated with arterial stiffness. Thus, their coexistence may be a crucial risk factor of arteriosclerosis. However, little is known about the cross relationships among muscle mass, visceral fat mass, and arterial stiffness in type 2 diabetes mellitus (T2DM).
METHODS: We recruited 97 postmenopausal women with T2DM and examine the association of muscle mass and visceral fat mass with brachial-ankle pulse wave velocity (baPWV). Relative skeletal muscle mass index (RSMI) and %trunk fat were evaluated by whole body dual-energy X-ray absorptiometry. Subcutaneous and visceral fat areas were measured by computed tomography.
RESULTS: Multiple regression analyses adjusted for age, duration of T2DM, systolic blood pressure, body mass index, HbA1c, serum creatinine, low-density lipoprotein-cholesterol, uric acid, and the usage of anti-hypertensive drug showed that RSMI was negatively associated with baPWV (β=-0.40, p=0.027), while %trunk fat and visceral fat area were positively associated with it (β=0.29, p=0.004 and β=0.51, p=0.001, respectively). Moreover, after additional adjustment for RSMI, %trunk fat and visceral fat area were positively associated with baPWV (β=0.26, p=0.010 and β=0.46, p=0.003, respectively) although the association between RSMI and baPWV became marginal after additional adjustment for %trunk fat or visceral fat area (β=-0.30, p=0.146 and β=-0.30, p=0.085, respectively).
CONCLUSIONS: Reduced muscle mass and increased visceral fat are independently associated with increased arterial stiffness in postmenopausal women with T2DM.
主題
Muscle mass
Atherosclerosis
Diabetes mellitus
Sarcopenia
Obesity
言語
英語
資源タイプ 学術雑誌論文
出版者
Elsevier
発行日 2016-12
権利情報
© 2016 Elsevier Ireland Ltd. All rights reserved.
出版タイプ Accepted Manuscript(出版雑誌の一論文として受付されたもの。内容とレイアウトは出版社の投稿様式に沿ったもの)
アクセス権 オープンアクセス
関連情報
[DOI] 10.1016/j.diabres.2016.10.014
[PMID] 27838345
[NCID] AA1044374X