Towards the development of a non-bioptic diagnostic technique for eosinophilic esophagitis using Raman spectroscopy

Vibrational spectroscopy 85 巻 7-10 頁 2016-07 発行
アクセス数 : 1733
ダウンロード数 : 172

今月のアクセス数 : 12
今月のダウンロード数 : 3
ファイル情報(添付)
vibspectrosc85_7.pdf 960 KB エンバーゴ : 2018-07-31
タイトル
Towards the development of a non-bioptic diagnostic technique for eosinophilic esophagitis using Raman spectroscopy
著者
Noothalapati Hemanth
上村 魁
Ando Masahiro
Hamaguchi Hiro-o
収録物名
Vibrational spectroscopy
85
開始ページ 7
終了ページ 10
収録物識別子
ISSN 09242031
内容記述
その他
Eosinophilic esophagitis (EoE) is believed to be a rare pathological condition that is characterized by dense infiltration of eosinophils in esophageal epithelial layer. Occurrence of this disease worldwide has started increasing rapidly in the last decade. Routine endoscopic observations can help in diagnosis only if clear longitudinal furrows or multiple concentric rings are observed but does not give any definitive conclusion in the early stages. Hence esophageal tissue samples are collected from multiple sites by biopsy and the number of eosinophils is counted after staining. Such a procedure is time consuming and has an inherent risk of bleeding, eventually damaging esophagus. Hence we developed a resonance Raman spectroscopy based approach to detect eosinophils in esophagus using mouse models. Our results show the presence of eosinophils in mice esophageal tissues suffering from inflammation by administering interleukin-33 while there are none in control mice. We believe this method can be used in clinical application for diagnosing EoE in the near future.
主題
Raman spectroscopy
Eosinophilic esophagitis
Non-bioptic diagnosis
Eosinophil peroxidase
言語
英語
資源タイプ 学術雑誌論文
出版者
Elsevier B.V.
発行日 2016-07
権利情報
© 2016 Elsevier B.V. All rights reserved.
出版タイプ Accepted Manuscript(出版雑誌の一論文として受付されたもの。内容とレイアウトは出版社の投稿様式に沿ったもの)
アクセス権 オープンアクセス
関連情報
[DOI] 10.1016/j.vibspec.2016.03.016
[NCID] AA10787250