Feasibility of HPV16, HPV18, and p16 Expression as Biomarkers for Distinguishing Normal Oral Epithelium From Oral Epithelial Dysplasia and Oral Intraepithelial Neoplasia

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Title
Feasibility of HPV16, HPV18, and p16 Expression as Biomarkers for Distinguishing Normal Oral Epithelium From Oral Epithelial Dysplasia and Oral Intraepithelial Neoplasia
Creator
Tsunematsu Koji
Nakatani Eiji
Iwahashi Teruaki
Karino Masaaki
Nariai Yoshiki
Kanno Takahiro
Kagimura Tatsuo
Source Title
Shimane journal of medical science
Volume 32
Issue 2
Start Page 69
End Page 79
Journal Identifire
ISSN 03865959
EISSN 24332410
Descriptions
This preliminary study evaluated the expression of human papilloma virus (HPV) 16, HPV18, and p16 as possible biomarkers to distinguish normal oral epithelium (NOE) from oral epithelial dysplasia (OED) and oral intraepithelial neoplasia (OIN). Subjects comprised 150 cases including 41 with OED, 30 with OIN, and 67 with oral squamous cell carcinoma (OSCC). NOE was also taken from 12 healthy participants. Staining indices of HPV16, HPV18, and p16 were immunohistochemically examined using paraffin-embedded specimens. A statistically significant difference was seen in the expression of HPV18 and p16 in OED/OIN compared with NOE and OSCC. Furthermore, regression tree analysis of independent variables, including p16 and HPV18 expression and the participants’ age, was performed to distinguish NOE from OED/OIN. In conclusion, this preliminary study demonstrated that p16 and HPV18 expression and participants’ age (60 years) can be used to distinguish NOE from OED/OIN.
Subjects
HPV16 , HPV18 , p16
oral epithelial dysplasia
oral intraepithelial neoplasia
oral squamous cell carcinoma
Language
eng
Resource Type departmental bulletin paper
Publisher
Shimane University Faculty of Medicine
Date of Issued 2016
Publish Type Version of Record
Access Rights open access
Relation
[NCID] AA00841586