Serum dipentidyl peptidase-4 is associated with multiple vertebral fractures in type 2 diabetes mellitus

Clinical endocrinology 84 巻 3 号 332-337 頁 2016-03 発行
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タイトル
Serum dipentidyl peptidase-4 is associated with multiple vertebral fractures in type 2 diabetes mellitus
著者
収録物名
Clinical endocrinology
84
3
開始ページ 332
終了ページ 337
収録物識別子
ISSN 03000664
内容記述
その他
Objective: Patients with type 2 diabetes mellitus (T2DM) have a high risk of fracture although they have slightly higher bone mineral density (BMD). There is no evidence that dipeptidyl peptidase-4 (DPP-4) is involved in the bone fragility of the patients. The aim of this study was to investigate the association between serum DPP-4 levels and vertebral fractures (VFs) in men with T2DM.
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Design: We conducted a cross-sectional study and investigated the relationships between serum DPP-4 levels vs BMD at lumbar spine, femoral neck and radius, bone turnover markers and presence of VFs in 204 Japanese male patients.
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Results: Multiple regression analyses adjusted for confounders such as age, duration of diabetes, body mass index, serum creatinine, HbA1c, serum albumin, log(alanine transaminase), and log(C-reactive protein) showed that serum DPP-4 was positively associated with bone formation markers (bone-specific alkaline phosphatase and osteocalcin) as well as a bone resorption marker [tartrate-resistant acid phosphatase 5b (TRACP-5b)] (β = 0・25, P < 0・01; β = 0・17, P < 0・05; and β = 0・30, P < 0・01, respectively), but not BMD at each site. Multivariate logistic regression analyses adjusted for the confounders described above revealed that serum DPP-4 levels were associated with the presence of multiple VFs (odds ratio 1・61, 95% confidential interval 1・05-2・49 per SD increase, P < 0・05). This association was still significant after additional adjustment for any sites of BMD or bone turnover markers except for TRACP-5b.
その他
Conclusions: We firstly showed that high level of serum DPP-4 is associated with prevalent multiple VFs independently of BMD and bone formation in men with T2DM.
言語
英語
資源タイプ 学術雑誌論文
出版者
Wiley
発行日 2016-03
権利情報
This is the peer reviewed version of the following article: Notsu M, Kanazawa I, Tanaka S, Yamaguchi T, Sugimoto T: Serum dipeptidyl peptidase-4 is associated with multiple vertebral fractures in type 2 diabetes mellitus. Clin Endocrinol 84(3): 332-337, 2016., which has been published in final form at http://dx.doi.org/10.1111/cen.12971. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
出版タイプ Accepted Manuscript(出版雑誌の一論文として受付されたもの。内容とレイアウトは出版社の投稿様式に沿ったもの)
アクセス権 オープンアクセス
関連情報
[DOI] 10.1111/cen.12971
[PMID] 26541263