Osteocalcin as a hormone regulating glucose metabolism

World journal of diabetes 6 巻 18 号 1345-1354 頁 2015-12 発行
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タイトル
Osteocalcin as a hormone regulating glucose metabolism
著者
収録物名
World journal of diabetes
6
18
開始ページ 1345
終了ページ 1354
収録物識別子
ISSN 19489358
内容記述
その他
The number of patients with osteoporosis and diabetes is rapidly increasing all over the world. Bone is recently recognized as an endocrine organ. Accumulating evidence has shown that osteocalcin, which is specifically expressed in osteoblasts and secreted into the circulation, regulates glucose homeostasis by stimulating insulin expression in pancreas and adiponectin expression in adipocytes, resulting in improving glucose intolerance. On the other hand, insulin and adiponectin stimulate osteocalcin expression in osteoblasts, suggesting that positive feedforward loops exist among bone, pancreas, and adipose tissue. In addition, recent studies have shown that osteocalcin enhances insulin sensitivity and the differentiation in muscle, while secreted factors from muscle, myokines, regulate bone metabolism. These findings suggest that bone metabolism and glucose metabolism are associated with each other through the action of osteocalcin. In this review, I describe the role of osteocalcin in the interaction among bone, pancreas, brain, adipose tissue, and muscle.
主題
Osteocalcin
Undercarboxylated osteocalcin
Glucose
Insulin
Adiponectin
Glucagon-like peptide-1
Diabetes mellitus
言語
英語
資源タイプ 学術雑誌論文
出版者
Baishideng Publishing Group
発行日 2015-12
権利情報
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
出版タイプ Version of Record(出版社版。早期公開を含む)
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関連情報
[DOI] 10.4239/wjd.v6.i18.1345
[PMID] 26722618