ファイル情報(添付) | |
タイトル |
Reduction in Endogenous Insulin Secretion is a Risk Factor of Sarcopenia in Men with Type 2 Diabetes Mellitus
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著者 |
田中 賢一郎
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収録物名 |
Calcified Tissue International and Musculoskeletal Research
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巻 | 97 |
号 | 4 |
開始ページ | 385 |
終了ページ | 390 |
収録物識別子 |
ISSN 0171967X
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内容記述 |
その他
Sarcopenia has recently attracted widespread attention, because it increases risks of fall and bedridden. Although patients with type 2 diabetes mellitus (T2DM) are known to have lower muscle mass of limbs than healthy people, the mechanism is still unclear. We thus examined the association of muscle mass with parameters of endogenous insulin secretion such as fasting immunoreactive insulin, fasting C-peptide immunoreactivity (CPR), and daily urine CPR in 191 men with T2DM. Muscle mass of arms and legs was evaluated by dual-energy X-ray absorptiometry, and we calculated relative skeletal muscle index (RSMI), which is useful for the diagnosis of sarcopenia. Multiple regression analyses adjusted for age, duration of T2DM, serum creatinine, HbA1c, and insulin-like growth factor-I showed that each parameter of endogenous insulin was significantly and positively correlated with muscle mass of arms and legs as well as RSMI (p < 0.05). Moreover, logistic regression analyses adjusted for confounding factors mentioned above showed that each parameter of endogenous insulin was significantly lower in subjects with sarcopenia than those without it (p < 0.05). In conclusion, reduction in endogenous insulin secretion is an independent risk factor of sarcopenia in men with T2DM.
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主題 |
Sarcopenia
Insulin secretion
Diabetes mellitus
Skeletal muscle mass
IGF-Ι
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言語 |
英語
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資源タイプ | 学術雑誌論文 |
出版者 |
Springer US
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発行日 | 2015-10 |
権利情報 |
The final publication is available at Springer via http://dx.doi.org/10.1007/s00223-015-9990-8.
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出版タイプ | Accepted Manuscript(出版雑誌の一論文として受付されたもの。内容とレイアウトは出版社の投稿様式に沿ったもの) |
アクセス権 | オープンアクセス |
関連情報 |
[DOI] 10.1007/s00223-015-9990-8
[PMID] 25850525
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